REVIEWpublished:19September2018doi:10.3389/fimmu.2018.01985FrontiersinImmunology|www.frontiersin.org1September2018|Volume9|Article1985Editedby:PhilippeGuilpain,UniversitéDeMontpellier,FranceReviewedby:MauricioRojas,UniversityofPittsburgh,UnitedStatesOrnellaParolini,UniversitàCattolicadelSacroCuore,Italy*Correspondence:ArduinoA.Mangoniarduino.mangoni@flinders.edu.auGianfrancoPintusgpintus@qu.edu.qaSpecialtysection:ThisarticlewassubmittedtoImmunologicalToleranceandRegulation,asectionofthejournalFrontiersinImmunologyReceived:13April2018Accepted:13August2018Published:19September2018Citation:ThuanDTB,ZayedH,EidAH,Abou-SalehH,NasrallahGK,MangoniAAandPintusG(2018)APotentialLinkBetweenOxidativeStressandEndothelial-to-MesenchymalTransitioninSystemicSclerosis.Front.Immunol.9:1985.doi:10.3389/fimmu.2018.01985APotentialLinkBetweenOxidativeStressandEndothelial-to-MesenchymalTransitioninSystemicSclerosisDuongThiBichThuan1,HatemZayed2,AliH.Eid2,3,4,HaissamAbou-Saleh4,GheyathK.Nasrallah2,5,ArduinoA.Mangoni6*andGianfrancoPintus2,5*1DepartmentofBiochemistry,HueUniversityofMedicineandPharmacy,UniversityofHue,Hue,Vietnam,2DepartmentofBiomedicalSciences,CollegeofHealthSciences,QatarUniversity,Doha,Qatar,3DepartmentofPharmacologyandToxicology,FacultyofMedicine,AmericanUniversityofBeirut,Beirut,Lebanon,4DepartmentofBiologicalandEnvironmentalSciences,CollegeofArtsandSciences,QatarUniversity,Doha,Qatar,5BiomedicalResearchCenter,QatarUniversity,Doha,Qatar,6DepartmentofClinicalPharmacology,CollegeofMedicineandPublicHealth,FlindersMedicalCentre,FlindersUniversity,Adelaide,SA,AustraliaSystemicsclerosis(SSc),anautoimmunediseasethatisassociatedwithanumberofgeneticandenvironmentalriskfactors,ischaracterizedbyprogressivefibrosisandmicrovasculaturedamageintheskin,lungs,heart,digestivesystem,kidneys,muscles,joints,andnervoussystem.Theseabnormalitiesareassociatedwithalteredsecretionofgrowthfactorandprofibroticcytokines,suchastransforminggrowthfactor-beta(TGF-β),interleukin-4(IL-4),platelet-deriv...
