CircularRNAMTO1actsasthespongeofmiR-9tosuppresshepatocellularcarcinomaprogressionDanHan1,2*,JiangxueLi1*,HuaminWang3,XiaopingSu2,JinHou2,YanGu2,ChengQian2,YunLin2,XiangLiu2,MingyanHuang2,NanLi2,WeipingZhou4,YizhiYu2,XuetaoCao1,2,31InstituteofImmunology,ZhejiangUniversitySchoolofMedicine,Hangzhou310058,China;2NationalKeyLaboratoryofMedicalImmunology&InstituteofImmunology,SecondMilitaryMedicalUniversity,Shanghai200433,China;3DepartmentofImmunology&CenterforImmunotherapy,InstituteofBasicMedicalSciences,PekingUnionMedicalCollege,ChineseAcademyofMedicalSciences,Beijing100005,China4ThirdDepartmentofHepaticSurgery,EasternHepatobiliarySurgeryHospital,Shanghai200438,China;*ThefirsttwoauthorscontributedequallytothisworkRunningtitle:circMTO1inhibitsHCCprogressionbydisruptingmiR-9Keywords:CircularRNA;hepatocellularcarcinoma;circMTO1;miR-9;p21Correspondingauthors:Dr.XuetaoCao,InstituteofImmunology,ZhejiangUniversitySchoolofMedicine,Hangzhou310058,China.Phone:(+86-571)88208284,Fax:(+86-571)88208085.E-mail:caoxt@immunol.org;orDr.YizhiYu,Thisarticlehasbeenacceptedforpublicationandundergonefullpeerreviewbuthasnotbeenthroughthecopyediting,typesetting,paginationandproofreadingprocesswhichmayleadtodifferencesbetweenthisversionandtheVersionofRecord.Pleasecitethisarticleasdoi:10.1002/hep.29270Thisarticleisprotectedbycopyright.Allrightsreserved.2NationalKeyLaboratoryofMedicalImmunology&InstituteofImmunology,SecondMilitaryMedicalUniversity,Shanghai200433,China.Phone:(+86-21)55620605;Fax:(+86-21)65382502;E-mail:yuyz@immunol.orgAbbreviations:circRNAs,cicularRNAs;circRIP,circRNAsinvivoprecipitation;CDK,cyclin-dependentkinase;FISH,FluorescenceinsituHybridization;HCC,hepatocellularcarcinoma;IHC,Immunohistochemistry;ISH,insituhybridization;kaps,K-adaptivepartitioningstatistical;miRNA,microRNA;RIP,RNAinvivoprecipitationFinancialSupportThisworkwassupportedbyGrantsfromNationalKeyBasicResearchProgramofChina(2014CB542101),theNationalNaturalScienceFoundationofChina(31390431,81123006,81571564)andCAM...
