Dependencyofatherapy-resistantstateofcancercellsonalipidperoxidasepathwayVasanthiS.Viswanathan1,MatthewJ.Ryan1,HarshilD.Dhrav2,ShubhrozGill1,OssiaM.Eichhoff3,BrintonSeashore-Ludlow1,SamuelD.Kaffenberger4,JohnK.Eaton1,KenichiShimada5,AndrewJ.Aguirre1,6,SrinivasR.Viswanathan1,6,ShrikantaChattopadhyay1,PabloTamayo1,7,WanSeokYang8,MatthewG.Rees1,SixunChen1,ZarkoVBoskovic1,SarahJavaid9,CherrieHuang1,XiaoyunWu1,Yuen-YiTseng1,ElisabethM.Roider3,DongGao4,JamesM.Cleary6,BrianM.Wolpin6,JillP.Mesirov1,7,DanielA.Haber9,10,JeffreyA.Engelman11,JesseS.Boehm1,JoanneD.Kotz1,CindyS.Hon1,YUChen4,WilliamC.Hahn1,6,MitchellP.Levesque3,JohnG.Doench1,MichaelE.Berens2,AlykhanF.Shamji1,PaulA.Clemons1,BrentR.Stockwell12,andStuartL.Schreiber1,10,131BroadInstitute,415MainStreet,Cambridge,Massachusetts02142,USA2CancerandCellBiologyDivision,TheTranslationalGenomicsResearchInstitute,445N5thStreet,Phoenix,Arizona85004,USA3DepartmentofDermatology,UniversityofZurich,UniversityHospitalofZurich,Wagistrasse14,CH-8952,Schlieren,Zürich,Switzerland4HumanOncologyandPathogenesisProgram,MemorialSloanKetteringCancerCenter,NewYork,NewYork10065,USA5LaboratoryofSystemsPharmacology,HarvardMedicalSchool,200LongwoodAvenue,Boston,Massachusetts02115,USA6DepartmentofMedicalOncology,DanaFarberCancerInstitute,Boston,Massachusetts02115,USA7MooresCancerCenter&DepartmentofMedicine,SchoolofMedicine,UniversityofCaliforniaSanDiego,LaJolla,California92093,USA8DepartmentofBiologicalSciences,St.John’sUniversity,8000UtopiaParkway,Queens,NewYork11439,USA9MassachusettsGeneralHospitalCancerCenter,14913thStreet,Charlestown,Massachusetts02129,USA10HowardHughesMedicalInstitute,ChevyChase,Maryland20815,USA11OncologyDiseaseArea,NovartisInstituteforBiomedicalResearch,Cambridge,Reprintsandpermissionsinformationisavailableatwww.nature.com/reprints.CorrespondenceandrequestsformaterialsshouldbeaddressedtoS.L.S.(stuart_schreiber@harvard.edu).OnlineContentMethods,alongwithanyadditionalExtendedDatadisplayitemsandSourceData,areavailableintheo...
