42DOl:10.16720/j.cnki.tcyj.2022.121SpecialWildEconomicAnimalandPlantResearch特产研究丹逍遥合剂对乳腺增生模型大鼠的药效学研究袁名扬1,李新1,丁匀乔1,周学刚2,蒋蕾2,杨波1*，彭海生2※（1.哈尔滨商业大学药学院，黑龙江哈尔滨150076;2.哈尔滨医科大学大庆校区药学院，黑龙江大庆163319)摘要：本研究通过复制大鼠乳腺增生模型，探讨丹逍遥合剂抗乳腺增生的作用。采用苯甲酸雌二醇一黄体酮联用对雌性SD大鼠进行肌内注射造模，造模后分为模型组，他莫昔芬组，丹逍遥合剂低、中、高剂量组，灌胃给药20d，治疗结束后计算胸腺和子宫指数，测量血清中雌二醇(E2)及孕酮(P)含量，观察大鼠乳腺病理组织形态。结果显示：同模型组相比，各组大鼠子宫指数明显下降，胸腺指数明显上升，E2含量降低，P水平增高，以上均有显著性差异。他莫昔芬组和丹逍遥合剂高剂量组乳腺组织病理形态基本接近正常组。丹逍遥合剂能抑制大鼠乳腺增生引起的乳头红肿和子宫肥大，同时调节血清激素水平，从而起到抗乳腺增生的作用。关键词：丹逍遥合剂；乳腺增生；药效学中图分类号：R285.5ThePharmacodynamicsStudiesofDanzhiXiaoyaoMixturesinMammaryGlandHyperplasiaModelRats文献标志码：A文章编号：1001-4721(2023)04-0042-05YUANMingyang',LiXin',DINGYunqiaol,ZHOUXuegang?,JiangLei2,YangBol*,PENGHaisheng2*(1.DepartmentofPharmacy,HarbinUniversityofCommerce,Harbin150076,China;2.DepartmentofPharmacy,DaqingCampus,HarbinMedicalUniversity,Daqing163319,China)Abstract:Inthisstudy,theanti-mammaryglandhyperplasiaeffectofDanzhiXiaoyaomixtureswasinvestigatedbyreplicatingtheratmodelofmammaryglandhyperplasia.FemaleSDratsweremodeledbyintramuscularinjectionofestradiolbenzoate-progesteronecombination.Aftermodeling,theyweredividedintothemodelgroup,tamoxifengroup,andDanzhiXiaoyaomixtureweredividedintothelow,mediumandhighdosegroup.Stomachadministrationfor20d.Afterthetreatment,thethymusanduterineindexeswerecalculated,theserumestra-diol(E2)andprogesterone(P)contentsweremeasured,andthehistopathologicalmorphologyoftheratmammaryglandswasobserved.Theresultsshowedthatcomparedwiththemodelgroup,theuterineindexoftheratsineachgroupwassignificantlydecreased,thethymusindexwassignificantlyincreased,theE2contentwasdecr...
