国际生殖健康/计划生育杂志2023年7月第42卷第4期JIntReprodHealth/FamPlan，July2023,Vol.42,No.4D0I:10.12280/gjszjk.20230024组织驻留巨噬细胞与卵巢常见疾病·323··综述·郭艳，刁瑞英，苏丹娜，汪丽萍【摘要】卵巢内存在复杂的神经-内分泌和免疫调控网络。组织驻留巨噬细胞（tissue-residentmacrophages,TRM)是一类存在于人体绝大多数组织器官、独立于外周循环且具有一定自我更新能力的固有免疫细胞，卵巢TRM是卵巢中最丰富的免疫细胞，主要驻留在卵泡膜、黄体、闭锁卵泡和间质组织等构成的微环境中;其数目、分布、功能稳态异常可影响卵泡发育（包括卵母细胞成熟和排卵等）,与女性不孕相关。卵巢TRM功能障碍会导致卵巢常见疾病发生，如卵巢子宫内膜异位囊肿、多囊卵巢综合征和早发性卵巢功能不全等。综述卵巢TRM的来源、生理功能及其功能异常对卵泡发育的影响机制,并对卵巢TRM功能障碍相关卵巢疾病进行深入探讨，旨在为卵巢功能障碍性疾病的治疗提供新的思路。【关键词】卵巢；巨噬细胞；细胞微环境；囊肿；多囊卵巢综合征；原发性卵巢功能不全Tissue-ResidentMacrophagesandCommonOvarianDiseasesGUOYan,DIAORui-ying,SUDan-na,WANGLi-ping.GuangdongMedicalUniversity,Zhanjiang524023,GuangdongProvince,China(GUOYan,WANGLi-ping);DepartmentofReproductiveMedicine,FirstAffiliatedHospitalofShenzhenUniversity,Shenzhen518035,GuangdongProvince,China(DIAORui-ying,SUDan-na,WANGLi-ping)Correspondingauthor:WANGLi-ping,E-mail:wlilyu@hotmail.com[Abstract】Intheovary,thereisacomplexneuroendocrineandimmuneregulatorynetwork.Tissue-residentmacrophages(TRMs)areakindofinnateimmunecellsthatexistinmosttissuesandorgansofhumanbody.TRMsareindependentoftheperipheralcirculation,withtheabilityofself-renewal.TRMsasthemostabundantimmunecellsintheovarymainlyresideinthemicroenvironmentthatiscomposedoffollicularmembrane,corpusluteum,atresiafolliclesandinterstitialtissue.Thedisorderofquantity,distributionandfunctionalhomeostasisofovarianTRMsisrelatedtofemaleinfertility,byaffectingfolliculardevelopment(includingoocytematurationandovulation).ThedysfunctionofovarianTRMscouldresultintheoccurrenceofcommonovariandiseases,includingendometriosis,polycysticovarysyndrome(PCOS)andprematureo...
