论著MTHFR基因C６７７T多态性与冠心病患者病情程度、合并症的相关性研究∗白志生吕永会∗∗(宝鸡市人民医院,陕西宝鸡７２１０００)[摘要]【目的】探讨亚甲基四氢叶酸还原酶(MTHFR)基因C６７７T多态性与冠心病患者病情程度、合并症的相关性.【方法】选择２０２１年１月至２０２２年１月本院收治的４９６例冠心病患者资料,根据MTHFR基因C６７７T多态性检测结果将其分为CC组(n＝１３９)、CT组(n＝２１１)、TT组(n＝１４６).比较三组患者冠心病病情程度、血浆同型半胱氨酸(Hcy)、血压水平,血清总胆固醇(TC)、甘油三酯(TG)、糖化血红蛋白(HbA１c)水平,统计三组中H型高血压、高血压、糖尿病、高脂血症发生率;分析MTHFR基因C６７７T多态性分型与Gensini评分、Hcy、TC、TG、HbA１c的相关性.【结果】三组患者Hcy、SBP、DBP、TC、TG、HbA１c、Gensini评分比较,差异均具有统计学意义(P＜０．０５).三组患者H型高血压、高血压、糖尿病、高脂血症合并症发生率比较,差异均具有统计学意义(P＜０．０５).【结论】MTHFR基因C６７７T多态性与冠心病患者病情程度、Hcy、血脂及血糖水平具有相关性,其中TT基因型冠心病患者病情程度严重的概率较高,且合并H型高血压、高血压、糖尿病、高脂血症的风险也更高.[关键词]冠心病;基因表达;多态现象,遗传;病人病情;数据相关性TheCorrelationbetweentheC６７７TPolymorphismofMTHFRGeneandtheSeverityandCoＧmorbiditiesofCoronaryHeartDiseasePatientsBAIZhiＧsheng,LYUYongＧhui(BaojiPeople＇sHospital,BaojiShaanxi７２１０００)[Abstract]【Objective】ToinvestigatethecorrelationbetweentheC６７７TpolymorphismofthemethyleＧnetetrahydrofolatereductase(MTHFR)geneandtheseverityandcomorbiditiesofcoronaryheartdiseasepaＧtients．【Methods】Atotalof４９６patientswithcoronaryheartdiseaseadmittedtoourhospitalfromJanuary２０２１toJanuary２０２２wereselectedanddividedintoCCgroup(n＝１３９),CTgroup(n＝２１１),andTTgroup(n＝１４６)basedontheMTHFRgeneC６７７Tpolymorphismdetectionresults．Theseverityofcoronaryheartdisease,plasmahomocysteine(Hcy),bloodpressure,andserumtotalcholesterol(TC),triglyceride(TG),andglycosylatedhemoglobin(HbA１c)werecomparedamongthethreegroups,andtheincidenceofHＧtypehyperＧtension,hypertension,diabetes,andhyperlipidemiainthethreegroupswerestati...
