天津中医药ＴｉａｎｊｉｎＪｏｕｒｎａｌｏｆＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅ２０23年9月第40卷第9期Sep.２０23,Ｖｏｌ．40Ｎｏ．9Changesinbrainfunctionalactivityinmigrainewithanxietyanddepressionandthemechanismofacupunctureonitsregulation：aMeta鄄analysisoffMRIstudiesCHENYing1，SUNJingqing2，HONGJiahui1，LIUYuhan1，CHENQiuyi2，LIULu2（1.BeijingUniversityofChineseMedicine，Beijing100029，China；2.BeijingKeyLaboratoryofAcupunctureNeuromodulation，DepartmentofAcupunctureandMoxibustion，BeijingHospitalofTraditionalChineseMedicine，CapitalMedicalUniversity，Beijing100010，China）Abstract：[Objective]Toevaluatethechangesofbrainfunctioninmigrainepatientswithanxietyanddepressionandtheeffectsofacupunctureonbrainfunction.[Methods]DomesticandforeigndatabasesweresearchedfromtheestablishmentofeachdatabasetoJune2022.Theliteratureonacupuncturetreatmentofmigrainewithoutaurausingfunctionalmagneticresonanceimaging（fMRI）astheobservationindexwassystematicallycollected，andtheclinicalbrainfunctionalimagestudiesofmigrainepatientswithanxietyanddepressionwerescreenedout，andthebrainfunctionalimagedataofacupuncturetreatmentonmigrainewithanxietyanddepressionweresummarized.ImageindicatorswererequiredtoincludeMNI（MontrealNeurologicalInstitute）orTalairachspatialcoordinatesofactivatedbrainregions，andvoxelMeta鄄analysiswasperformedusingSeed鄄baseddMapping（SDM）software.Thecharacteristicsofbrainfunctionchangeandthegeneralruleofbrainfunctionchangecausedbyacupuncturetreatmentofthisdiseasewereobtained.[Results]Atotalof186literatureswereretrieved，10ofwhichmettheinclusioncriteria，including418patientsand160healthycontrols.VoxelMeta鄄analysisofthe10studiesshowedthatthebrainfunctionoftheleftcaudatenucleusinmigrainewithanxietyanddepressionwasmoreactivethanthatinthehealthycontrol，andtheactivityofthebilateralmiddleoccipitalgyrusandrightsuproccipitalgyruswaslessactivethanthatinthehealthycontrol.Acupuncturedecreasedthebrainfunctionintherightmiddlefrontalgyrus（P<0.005）.[Conclusion]A...
