第52卷第4期第574页2023年8月华中科技大学学报(医学版)ActaMedUnivSciTechnolHuazhongVol.52No.4P.574Aug.2023*国家自然科学基金资助项目(No.81573787)杨立,女,1993年生,医学硕士,E-mail:1979422122@qq.com△通讯作者,Correspondingauthor,E-mail:905244619@qq.comPCOS中肥胖、胰岛素抵抗与炎症的关系*杨立1,程玲2,王志1,黄冬梅1△1华中科技大学同济医学院附属同济医院中西医结合研究所,武汉4300302同济大学附属东方医院针灸科,上海200120摘要:多囊卵巢综合征(polycysticovarysyndrome,PCOS)是常见的内分泌紊乱疾病,PCOS患者常因排卵障碍导致不孕。肥胖和胰岛素抵抗(insulinresistance,IR)在PCOS的发生发展中具有重要作用。有研究发现,PCOS患者呈现出一种慢性低水平炎症状态,这种炎症状态受到多种因素的影响,尤其是肥胖和胰岛素抵抗。该文对肥胖、胰岛素抵抗与炎症的关系,以及肥胖和胰岛素抵抗对PCOS患者炎症状态的影响进行了综述。关键词:多囊卵巢综合征;炎症;肥胖;胰岛素抵抗中图分类号:R711.75DOI:10.3870/j.issn.1672-0741.2023.04.024EffectsofObesityandInsulinResistanceonInflammatoryStateofPatientswithPolycysticOvarySyndromeYangLi1,ChengLing2,WangZhi1etal1InstituteofIntegratedTraditionalChineseandWesternMedicine,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China2DepartmentofAcupunctureandMoxibustion,EastHospital,TongjiUniversity,Shanghai200120,ChinaAbstractPolycysticovarysyndrome(PCOS)isacommonendocrinedisorderandoftencausesinfertilityduetoovulationdysfunction.Obesityandinsulinresistance(IR)playimportantrolesinthedevelopmentofPCOS.IthasbeenfoundthatPCOSpatientsareofteninachroniclowlevelinflammatorystate,whichisaffectedbyavarietyoffactors,especiallyobesityandIR.Therelationshipbetweenobesity,IRandinflammation,andtheeffectofobesityandIRonthelowlevelinflammatorystateofPCOSarereviewedinthispaper.Keywordspolycysticovarysyndrome;inflammation;obesity;insulinresistance多囊卵巢综合征(polycysticovarysyndrome,PCOS)是育龄期妇女最常见的内分泌紊乱性疾病,以卵巢多囊样改变、排卵障碍、高雄激素血症和胰岛素抵抗(insulinresistance,IR)为主要特征,临床上主要表现为月经失调、不孕、肥胖、多毛、痤疮和黑棘皮症等。关于PCOS的...
