·临床医学研究·布林佐胺滴眼液在青光眼治疗中的疗效观察与安全性分析李彬,晁小蕊,洪萌,谢艳艳,石荣先河南大学第一附属医院眼科,河南开封475000摘要目的:对马来酸噻吗洛尔滴眼液单用与马来酸噻吗洛尔滴眼液结合布林佐胺滴眼液两种治疗青光眼方法的临床疗效进行对比分析,并了解其安全性。方法:选取某院2015年3月至2020年3月收治的青光眼患者92例,随机分为G组与D组,各46例。D组患者治疗仅仅用马来酸噻吗洛尔滴眼液,G组患者治疗采用马来酸噻吗洛尔滴眼液结合布林佐胺滴眼液的方法,对G组和D组两组患者治疗前后的疗效、心率、眼压以及不良反应率进行对比。结果:两组患者治疗2、4、8周后眼压均较治疗前显著下降,且G组下降幅度大于D组(P<0.05);两组发生不良反应率没有明显差异,无统计学意义(P>0.05)。结论:在青光眼治疗中,马来酸噻吗洛尔滴眼液与布林佐胺滴眼液联用疗效较佳,且不良反应发生率较低,值得推广应用。关键词青光眼;马来酸噻吗洛尔滴眼液;布林佐胺滴眼液中图分类号R775EfficacyandsafetyanalysisofbrinzolamideeyedropsinthetreatmentofglaucomaLIBinCHAOXiaoruiHONGMengXIEYanyanSHIRongxianDepartmentofOphthalmologytheFirstAffiliatedHospitalofHenanUniversityKaifeng475000CHNAbstractObjectiveTocomparetheclinicaleffectsoftimololmaleateeyedropsaloneandbrinzolamideeyedropscombinedinthetreatmentofglaucomaMethodsAtotalof92glaucomapatientswithconsentinourhospitalbetweenMarch2015andMarch2020wereselectedandrandomlydividedintogroupGandgroupDeachwith46casesPatientsingroupDweretreatedwithtimololmaleateeyedropsaloneandpatientsingroupGweretreatedonthebasisofthetreatmentofpatientsingroupDwithextrabrinzolamideeyedropsThetreatmenteffectintraocularpressureheartrateandtheincidenceofadversereactionsaftermedicationinthetwogroupswereobservedResultsAfter2weeks4weeksand8weeksthanbeforetreatmentandthedecreaseingroupGwasgreaterthaninGroupDP<005therewasnodifferenceinadverseeffectsP>005ConclusionInthetreatmentofglaucomatimololmaleateeyedropscombinedwithbrinzolamideeyedropshaveabettereffectandthesideeffectingislessItisworthyusingforthetreatmentofglaucomaintheclinicKeywordsglaucomatimololmaleateeyedropsbrinzolamideeyedrops青光眼是由于眼压进行性升高,导致视神经功能出现进行...
