Vol.9No.4Aug.2023生物化工BiologicalChemicalEngineering第9卷第4期2023年8月文章编号：2096-0387（2023）04-04CUMS抑郁小鼠模型海马氧化损伤的研究及大黄酚的保护作用蔡依琳，朱乐玫*，陈彬，李千喜，陈光领（长沙医学院，湖南长沙410200）摘要：目的：探讨大黄酚（Chrysophanol，CHR）对于慢性不可预见性温和刺激（CUMS）导致的抑郁小鼠氧化应激的影响。方法：采用CUMS方法建立小鼠抑郁模型，分析不同剂量大黄酚对小鼠抑郁样行为的变化和小鼠海马组织超氧化物歧化酶（SOD）和丙二醛（MDA）水平的影响。结果：CHR能显著增加抑郁模型小鼠的体重，提高糖水偏好百分比，显著降低小鼠海马体中MDA水平，显著升高小鼠海马体SOD水平。结论：大黄酚能有效改善CUMS大鼠的抑郁样行为，其机制可能与氧化应激的调控有关。关键词：大黄酚；慢性不可预知性温和刺激；抑郁症；抗抑郁；氧化应激中图分类号：R932；R749.053文献标识码：ATheImprovementEffectsandMechanismofChrysophanolonCUMSDepressiveModelMiceCAIYilin,ZHULemei*,CHENBin,LiQianxi,CHENGuangling(ChangshaMedicalUniversity,Changsha410200,China)Abstract:Objective:Toinvestigatetheimprovementeffectsofchrysophanol(CHR)onmiceinducedbychronicunpredictablemildstress(CUMS)stimulation,andtoexplorethepossiblemechanism.Methods:Inthisstudy,theCUMSmethodisemployedtoestablishamurinemodelofdepressioninordertoinvestigatetheeffectsofvaryingdosesofCHRondepressive-likebehaviorsaswellastheimpactonthelevelsofsuperoxidedismutase(SOD)andmalondialdehyde(MDA)inthehippocampaltissueofmice.Results:CHRcansignificantlyincreasetheweightofdepressionmodelmice,increasethepercentageofsugarpreference,significantlyreducethelevelofMDAinthehippocampusofmice,andsignificantlyincreasethelevelofSODinthehippocampusofmice.Conclusion:Chrysophanolcaneffectivelyimprovethebehavioralsymptomsofdepressiveratsbyregulatingthefunctionsofoxidativestressprobably.Keywords:chrysophanol;chronicunpredictablemildstressmice;depression;antidepressant;oxidativestress抑郁症是最常见的精神障碍疾病之一，对患者的身心健康具有严重影响，全球约有三亿人受到抑郁症的困扰且发病率逐年上升[1]。抑郁症具有高患病率、高复发率和高致残率的特点，对患者家庭及社会带来了沉重的...
