764·临床研究·ThULEP与HoLEP治疗良性前列腺增生疗效比较的Meta分析周英豪，余皖东，马杭彬，张雪虎，周程，施国伟（复旦大学附属上海市第五人民医院泌尿外科，上海200240）EfficacyofThULEPversusHoLEPintreatingbenignprostatichyperplasia:aMetaanalysisZHOUYinghao,YUWandong,MaHangbin,ZHANGXuehu,ZHOUCheng,SHIGuowei(DepartmentofUrology,TheFifthPeople'sHospitalofShanghai,FudanUniversity,Shanghai200240,China)ABSTRACT:ObjectiveTocomparetheefficacyandsafetyofthuliumlaserenucleationoftheprostate(ThULEP)andholmiumlaserenucleationoftheprostate(HoLEP)inthetreatmentofbenignprostatichyperplasia(BPH).MethodsRandomizedcontrolledtrials（RCTs)andclinicalcontrolledtrials（CCTs)weresearchedinPubMed,Embase,CochraneLibrary,CNKIandWanfangDatabasefromJan.1,2010toMay30,2022.Tworeviewersindependentlyscreenedliterature,extracteddata,andassessedtheriskofbiasofincludedstudies.Alldivergenceswereresolvedbyathirdresearcher.RevMan5.4softwarewasusedforMetaanalysis.ResultsAtotalof7studieswereincluded,involving1726patients,750intheThULEPgroupand976intheHoLEPgroup.Metaanalysisshowedthat,comparedwithHoLEPgroup,theThULEPgrouphadshortercatheterindwellingtime[MD=-0.10,95%CI(-0.17--0.03),P=0.004],shorterhospitalstay[MD=-0.43,95%CI(-0.60--0.25),P<0.00001],lowerIPSSscore12monthsaftersurgery[MD=-1.13,95%CI(-1.95--0.30),P=0.007],lowerQoLscore12monthsaftersurgery[MD=-1.00,95%CI(-1.19--0.81),P<0.001],lowertransfusionrate[OR=0.11,95%CI(0.03-0.36),P=0.0003]andlowerincidenceofurinaryincontinence[OR=0.24,95%CI(0.09-0.66),P=0.006J.ConclusionThULEPmayhavesimilarefficacyandsafetyasHoLEPinthetreatmentofBPH,andhasmoreadvantagesinsomeaspects.KEYWORDS:thuliumlaserenucleationoftheprostate;holmiumlaserenucleationoftheprostate;benignprostatichyperplasia;Metaanalysis;systematicreview摘要：目的通过Meta分析比较激光前列腺刻除术(ThULEP)与铁激光前列腺切除术（HoLEP)治疗良性前列腺增生（BPH)的疗效和安全性。方法计算机检索PubMed、Embase、CochraneLibrary、中国知网、万方等数据库，收集比较ThULEP和HoLEP治疗BPH的随机对照试验及对照临床试验，检索时限从2...
