2023年2月第30卷第2期替格瑞洛联合阿司匹林对急性心肌梗死患者左心室功能指标及炎性因子水平的影响邓林，季翔，魏艳霞*（南阳市中心医院康复医学科，河南南阳473000）【摘要】目的探讨替格瑞洛联合阿司匹林在急性心肌梗死（AMI）患者中的应用效果。方法120例AMI患者随机分为两组，对照组给予氯吡格雷联合阿司匹林治疗，观察组给予替格瑞洛联合阿司匹林治疗，比较两组的左心室功能指标、炎性因子水平及不良反应。结果治疗后，观察组的LVEDD、IL－6、TNF－α、hs－CRP以及不良反应发生率均低于对照组，LVEF高于对照组（P＜0．05）。结论替格瑞洛联合阿司匹林可明显改善AMI患者左心室功能，减轻机体炎性反应，降低不良反应发生率。【关键词】替格瑞洛；阿司匹林；急性心肌梗死；左心室功能；炎性因子中图分类号：R542.2+2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0199ImpactofTicagrelorCombinedwithAspirinonLeftVentricularFunctionIndicatorsandLevelsofInflammatoryFactorsinPatientswithAcuteMyocardialInfarction//DENGLin,JIXiang,WEIYanxia*(DepartmentofRehabilitationMedicine,NanyangCentralHospital,Nanyang473000,China;*Correspondingauthor:WEIYanxia,E-mail:2451058086@qq.com)[Abstract]ObjectiveToexploretheapplicationeffectofticagrelorcombinedwithaspirininpatientswithacutemyocardialinfarction(AMI).Methods120AMIpatientswererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithclopidogrelcombinedwithaspirin,andtheobservationgroupwastreatedwithticagrelorcombinedwithaspirin.Theleftventricularfunctionindicators,levelsofinflammatoryfactors,andadversereactionswerecomparedbetweenthetwogroups.ResultsAftertreatment,theLVEDD,IL-6,TNF-α,hs-CRP,andincidenceofadversereactionsoftheobservationgroupwerelowerthanthoseofthecontrolgroup,andLVEFwashigherthanthatofthecontrolgroup(P<0.05).ConclusionsTicagrelorcombinedwithaspirincanobviouslyimprovetheleftventricularfunctionofAMIpatients,relievebody'sinflammatoryresponse,andreducetheincidenceofadversereactions.[Keywords]Ticagrelor;Aspirin;Acutemyocardialinfarction;Leftventricularfunction;Inflammatoryfactor急性心肌梗死（acutemyocardialinfarction，AMI）主要是由冠状动脉病变导致血管堵塞、狭窄，使得心肌...
