临床医学研究与实践2023年3月第8卷第7期EffectofbruceajavanicaoilemulsioninjectioncombinedwiththymopentininthepalliativetreatmentofstageⅣnon-smallcelllungcancerwithoutdrivergeneZHUJie(OncologyDepartment,TaizhouCityHospitalofTraditionalChineseandWesternMedicine,Taizhou225300,China)ABSTRACT:ObjectiveToanalyzetheeffectofbruceajavanicaoilemulsioninjectioncombinedwiththymopentininthepalliativetreatmentofstageⅣnon-smallcelllungcancerwithoutdrivergene.MethodsEightypatientswithstageⅣnon-smallcelllungcancerwithoutdrivergenetreatedinourhospitalfromApril2017toNovember2019wereselectedanddividedintocontrolgroupandobservationgroupaccordingtodifferenttreatmentschemes,with40casesineachgroup.Thecontrolgroupwasgiventhymopentinpalliativetreatment,whiletheobservationgroupwasgivenbruceajavanicaoilemulsioninjectioncombinedwiththymopentinpalliativetreatment.Thetherapeuticeffectsofthetwogroupswerecompared.ResultsThetotaleffectiverateoftreatmentintheobservationgroupwashigherthanthatinthecontrolgroup(P<0.05).Aftertreatment,thepeakexpiratoryflow(PEF),forcedvitalcapacity(FVC)andforcedexpiratoryvolumeinonesecond(FEV1)intheobservationgroupwerehigherthanthoseinthecontrolgroup(P<0.05).Aftertreatment,theclusterofdifferentiation3positive(CD3+)andclusterofdifferentiation4positive(CD4+)intheobservationgroupwerehigherthanthoseinthecontrolgroup,theclusterofdifferentiation8positive(CD8+)waslowerthanthatinthecontrolgroup,andtheCD4+/CD8+washigherthanthatinthecontrolgroup(P<0.05).Aftertreatment,thelevelsofinterleukin-6(IL-6),tumornecrosisfactor-α(TNF-α)intheobservationgroupwerelowerthanthoseinthecontrolgroup,andthelevelofinterleukin-10(IL-10)washigherthanthatinthecontrolgroup(P<0.05).Aftertreatment,thelevelsofcarcinoembryonicantigen(CEA),carbohydrateantigen125(CA125),carbohydrateantigen19-9(CA19-9)intheobservationgroupwerelowerthanthoseinthecontrolgroup,andthescoreofKarnofskyPerformanceStatus(KPS)washigherthanthatinthecontrolgroup(P<0.05).Thesurvivaltimeoftheobservationgroupwaslongerthanthatofthecontro...
