·经验交流·右美托咪定经鼻喷雾对食管癌根治术患者术后睡眠质量的影响王文燕张沛重【摘要】目的观察右美托咪定经鼻喷雾对患者术后睡眠质量的影响。方法选择2020年3月—2021年9月本院胸外科拟行食管癌根治术患者80例作为研究对象,按随机数表法分为对照组(N组)和观察组(D组)两组,每组各40例。观察组于术后当晚和术后1d晚上予以右美托咪定1μg/kg进行药物雾化喷鼻;对照组予以相同体积的生理盐水。记录并评估患者术后睡眠质量评分、尿褪黑素浓度及不良反应的发生情况。结果与对照组比较,观察组术后1d、2d的PSQI评分明显降低,尿褪黑素浓度明显升高(P<0.05);两组患者术后不良反应的发生率比较无统计学差异(P>0.05)。结论右美托咪定经鼻喷雾可改善食管癌根治术患者术后睡眠质量。【关键词】右美托咪定;食管癌;睡眠质量[中图分类号]R735.1[文献标识码]ADOI:10.3969/j.issn.1002-1256.2023.02.004EffectofdexmedetomidinenasalsprayonsleepqualityinpatientsundergoingradicalesophagectomyWangWenyan,ZhangPeizhong.Veinallocationcenter(WangWenyan)&DepartmentofAnesthesiaandPerioperativeMedicine(ZhangPeizhong),thefirstaffiliatedhospitalofNanyangMedicalCollege,Nanyang,Henan,473000,China.Correspondingauthor:ZhangPeizhong,Email:han3076704@126.com.【Abstract】ObjectiveToobservetheeffectofdexmedetomidinenasalsprayonpostoperativesleepqualityofpatients.MethodsAtotalof80patientswhoplannedtoundergoradicalesophagectomyinthoracicsurgerydepartmentofourhospitalfromMarch2020toSeptember2021...