临床医学研究与实践2023年3月第8卷第9期难治性产后出血是指产妇娩出胎儿1h内发生严重出血，经保守治疗无效，出血量达到1500mL以上或已发ClinicaleffectofcarboprosttromethamineinjectioncombinedwithBakriballoonintrauterinetamponadeinthetreatmentofrefractorypostpartumhemorrhageSHANGWeiwei,YANGXiaotang*(GynecologyandObstetricsDepartment,ZhangyePeople'sHospitalAffiliatedtoHexiUniversity,Zhangye734000,China)ABSTRACT:ObjectiveToexploretheclinicaleffectofcarboprosttromethamineinjectioncombinedwithBakriballoonintrauterinetamponadeinthetreatmentofrefractorypostpartumhemorrhage.MethodsSixtypatientswithrefractorypostpartumhemorrhageadmittedinourhospitalfromMarch2020toMarch2022wereselectedastheresearchobjects.Thepatientsweredividedintocontrolgroupandobservationgroupaccordingtotherandomnumbertablemethod,with30casesineachgroup.Thecontrolgroupwastreatedwithuterinearteryembolization,andtheobservationgroupwastreatedwithcarboprosttromethamineinjectioncombinedwithBakriballoonintrauterinetamponade.Theclinicalindexes,ovarianfunctionindexes,menstruation,hysterectomyrate,puerperalinfectionrateandqualityoflifewerecomparedbetweenthetwogroups.ResultsThehemostasistimeoftheobservationgroupwasshorterthanthatofthecontrolgroup,andthetotalbloodlossandhospitalizationexpenseswerelessthanthoseofthecontrolgroup(P<0.05).After42doftreatment,thelevelsoffolliclestimulatinghormone(FSH),luteinizinghormone(LH)andestradiol(E2)intheobservationgroupwerehigherthanthoseinthecontrolgroup(P<0.05).Thefirstmenstrualrecoverytimeoftheobservationgroupwasshorterthanthatofthecontrolgroup(P<0.05);therewerenosignificantdifferencesinthefirstmenstrualvolume,menstrualcycleandmenstrualdaysbetweenthetwogroups(P>0.05).Therewerenosignificantdifferencesinhysterectomyrateandpuerperalinfectionratebetweenthetwogroups(P>0.05).At42daftertreatment,thescoresofeachdimensionoftheMOS36-ItemShortFormHealthSurvey(SF-36)intheobservationgroupwerehigherthanthoseinthecontrolgroup(P<0.05).ConclusionCarboprosttromethamineinjectioncombinedwithBakriballoonint...
