第44卷第6期2023年6月安徽医学AnhuiMedicalJournal脾切除术治疗Wilson病合并脾亢患者的血液学改变及临床疗效蒋雨晨赵静刘力生胡文彬汪世靖韩永升吴君霞张琦李波张兵［摘要］目的探索Wilson病（WD）合并脾功能亢进患者血液肝功能等指标与其脾脏大小相关性，及脾脏切除的临床疗效。方法回顾性分析2018年1月至2021年12月在安徽中医药大学神经病学研究所附属医院住院的63例行脾切除术的WD患者的临床资料，并收集行脾切除术前、后的病例资料，采用Spearman相关性分析脾切除前后血液肝功能等指标与脾脏大小相关性。结果采用Spearman相关性分析法得出脾脏厚度与PLT（r=-0.54，P<0.001）呈负相关，与PT（r=0.28，P=0.026）、SOD（r=0.28，P=0.028）、TBA（r=0.30，P=0.017）、TBIL（r=0.36，P=0.004）呈正相关。脾脏长度与PLT（r=-0.37，P=0.003）呈负相关、与TBA（r=0.28，P=0.025）呈正相关。WD患者脾切除后SOD、ALB、PLT水平较术前升高，PT以及TBIL水平较术前下降，差异有统计学意义（P<0.05）。结论脾切除术对WD合并脾亢患者的PLT下降具有改善作用，可部分改善肝脏的解毒、代谢、合成等功能指标，并对改善凝血功能具有积极影响。［关键词］WD；脾功能亢进；脾切除术；血液学指标doi:10.3969/j.issn.1000-0399.2023.06.004HematologicalchangesandclinicalefficacyofsplenectomyintreatmentofWilson'sdiseasewithhypersplenismJIANGYucheng1，ZHAOJing1，LIULisheng2，HUWenbin2，WANGShijing2，HANYongsheng2，WUJunxia3，ZHANGQi3，LIBo4，ZHANGBin51.SpecialExaminationDepartmentofAffiliatedHospitalofneurologyResearchInstituteofAnhuiHefeiUniversityofTraditionalChineseMedicine,Hefei230061,China2.DepartmentofNeurology,AffiliatedHospitalofneurologyResearchInstitute,AnhuiUniversityofTraditionalChineseMedicine,Hefei230061,China3.LaboratoryDepartmentofneurologyResearchInstituteofAnhuiUniversityofTraditionalChineseMedicine，Hefei230061,China4.DepartmentofTraditionalChineseMedicineEncephalopathy,AffiliatedHospitalofneurologyResearchInstitute,AnhuiUniversityofTra⁃ditionalChineseMedicine,Hefei230061,China5.GraduateSchoolofAnhuiUniversityofTraditionalChineseMedicine,Hefei230061,ChinaFundingProject:GeneralProjectoftheNationalNaturalScienceFoundationofChina(No.81473535),AnhuiUniversityofTradit...
