doi:10.13407/j.cnki.jpp.1672-108X.2023.07.004·论著·11例万古霉素引起儿童药物热报道并文献复习彭静,徐华,李新林,李巧玲(华中科技大学同济医学院附属武汉儿童医院,武汉430016)作者简介:彭静(1982.09-),女,硕士,副主任药师,主要从事临床药学工作,E-mail:pengjing2008@sina.com。[摘要]目的:探讨儿童应用万古霉素引起药物热的临床特点,为临床安全合理用药提供参考。方法:收集华中科技大学同济医学院附属武汉儿童医院2017年7月至2021年6月应用万古霉素引起药物热的住院患儿,并对国内儿童使用万古霉素引起药物热的病例报道进行文献复习,总结用药剂量、药物热发生时间、不良反应处理及转归情况。结果:共收集万古霉素引起药物热的患儿11例,其中我院4例,文献报道7例。药物热发热时间5.0(2.0~10.0)d,最高体温39.1(38.3~40.0)℃,停药后退热时间1.9(1.0~3.0)d,可伴随其他器官和全身不良反应,发热期间实验室检查结果未见感染指标明显升高,停药后预后良好。结论:万古霉素引起儿童药物热与感染性疾病的发热较难鉴别,应结合药物使用时间、实验室检查结果及患儿发热特点加以判断,及时停用可疑药物,避免出现严重不良反应。[关键词]万古霉素;药物热;儿童[中图分类号]R939.3[文献标识码]A[文章编号]1672-108X(2023)07-0014-04ElevenCasesofVancomycin-InducedDrugFeverinChildrenandLiteratureReviewPengJing,XuHua,LiXinlin,LiQiaoling(WuhanChildren’sHospital,TongjiMedicalCollege,HuazhongUniversityofScience&Technology,Wuhan430016,China)[Abstract]Objective:Toinvestigatetheclinicalcharacteristicsofvancomycin-induceddrugfeverinchildren,soastoprovidereferenceforthesafetyofclinicaldruguse.Methods:Childrenwithvancomycin-induceddrugfeveradmittedintoWuhanChildren’sHospital,TongjiMedicalCollege,HuazhongUniversityofScience&TechnologyfromJul.2017toJun.2021werecollected.Literaturereviewwasconductedonthecasereportsofvancomycin-induceddrugfeverinchildreninChina,andthedrugdosage,duration,adversedrugreactionsymptomsandoutcomesweresummarized.Results:Atotalof11childrenwithvancomycin-induceddrugfeverwereenrolled,including4casesinourhospitaland7casesreportedinliterature.Thedurationofdrugfeverwas5.0(from2.0to10.0)d,themaximumbodytemperaturewas39.1(from38.3to40.0)℃,andthedurationoffeverremissionwas1...
