2023年4月国际神经病学神经外科学杂志Vol.50No.2第50卷第2期JournalofInternationalNeurologyandNeurosurgeryApr.2023脑转移瘤切除的“超边缘”理念公维昭,蒋太鹏,左大辉深圳市第二人民医院神经外科,广东深圳518000摘要:脑转移瘤(BM)是一些恶性肿瘤的常见并发症,手术作为神经外科治疗颅脑肿瘤最传统的方式依然发挥着不可替代的作用。BM的传统全切手术后往往复发率较高,越来越多的临床与病理证据支持该类肿瘤与正常脑组织并非界限分明,致使脑转移瘤的“超边缘切除”应运而生。鉴于脑功能的保护,应用之初仅限于非功能区,现如今已携手电生理检测、导航系统、术中唤醒等精密手段走进功能区,并基于微创理念在手术入路、瘤体切除等方面不断尝试,努力在最大范围切除肿瘤与保护脑功能之间做到最优化。通过回顾大量BM的超边缘切除相关研究,该文系统阐述了该手术理念的发生与发展。[国际神经病学神经外科学杂志,2023,50(2):77-81]关键词:脑肿瘤;转移瘤;外科治疗;电生理监测;神经导航;术中唤醒;扩大切除中图分类号:R739.41DOI:10.16636/j.cnki.jinn.1673-2642.2023.02.016SupramarginalresectionofbrainmetastasesGONGWeizhao,JIANGTaipeng,ZUODahuiNeurosurgeryDepartment,TheSecondPeople'sHospitalofShenzhen,Shenzhen,Guangdong518000,ChinaAbstract:Brainmetastases(BM)areacommoncomplicationofsomemalignanttumors,andsurgerystillplaysanirreplaceableroleasthemosttraditionalmethodforneurosurgicaltreatmentofcranialtumors.However,thereisoftenahighrecurrencerateafterconventionaltotalresectionofcranialmetastases,andanincreasingnumberofclinicalandpathologicalevidencehasshownthattherearenoclearboundariesbetweenthesetumorsandnormalbraintissue,whichleadstothedevelopmentof"supramarginalresection"ofbrainmetastases.Itwasinitiallylimitedtonon-functionalareastoprotectbrainfunction,andnowithasbeenappliedtofunctionalareasincombinationwiththesophisticatedtoolssuchaselectrophysiologicalexamination,navigationsystems,andintraoperativewake-up.Attemptshavebeenmadeonsurgicalapproachandtumorresectionbasedontheconceptofnoninvasiveness,soastoachieveanoptimaleffectbetweenthemaximumextentoftumorresectionandthemaximumpreservationofbrainfunction.Thisarti...