《癌症进展》2023年3月第21卷第6期ONCOLOGYPROGRESS,Mar2023Vol.21,No.6*论著*脑胶质瘤患者血清脑胶质瘤患者血清miRNA-miRNA-42954295、miRNA-miRNA-3434a水平及临床意义水平及临床意义代全德1#，徐忠海1，肖志强2商丘市第一人民医院1神经内科，2神经外科，河南商丘4761000摘要摘要：目的目的探讨脑胶质瘤患者血清miRNA-4295、miRNA-34a水平及临床意义。方法方法选取41例脑胶质瘤患者和41例健康体检者，分别作为观察组和对照组，检测两组受试者血清miRNA-4295、miRNA-34a水平，比较不同分化程度、不同预后脑胶质瘤患者血清miRNA-4295、miRNA-34a水平。结果结果观察组患者血清miRNA-4295、miRNA-34a水平均明显低于对照组，差异均有统计学意义（P﹤0.01）。分化程度为Ⅲ~Ⅳ级的脑胶质瘤患者血清miRNA-4295、miRNA-34a水平均低于Ⅰ~Ⅱ级患者，差异均有统计学意义（P﹤0.05）。截至2022年11月，41例脑胶质瘤患者中，死亡18例，生存23例。生存脑胶质瘤患者血清miRNA-4295、miRNA-34a水平均高于死亡患者，差异均有统计学意义（P﹤0.05）。结论结论脑胶质瘤患者血清miRNA-4295、miRNA-34a水平较低，且随着分化程度进展而逐渐降低，死亡患者的血清miRNA-4295、miRNA-34a水平较生存患者低。关键词关键词：脑胶质瘤；miRNA-4295；miRNA-34a中图分类号中图分类号：R739739.4141文献标志码文献标志码：AdoiAdoi：10.11877/j.issn.1672-1535.2023.21.06.21LevelsofmiRNA-LevelsofmiRNA-42954295andmiRNA-andmiRNA-3434ainpatientswithgliomaandtheirclinicalainpatientswithgliomaandtheirclinicalsignificancesignificanceDAIQuande1#,XUZhonghai1,XIAOZhiqiang21DepartmentofNeurology,2DepartmentofNeurosurgery,theFirstPeople’sHospitalofShangqiu,Shangqiu476100,He’nan,ChinaAbstractAbstract:ObjectiveObjectiveToexploretheserumlevelsofmiRNA-4295andmiRNA-34ainpatientswithgliomaandtheirclinicalsignificance.MethodMethodAtotalof41patientswithgliomaand41healthysubjectswereselectedintotheobserva‐tiongroupandthecontrolgroup.ThelevelsofmiRNA-4295andmiRNA-34ainbothgroupsweredetected.TheserummiRNA-4295andmiRNA-34ainpatientswithdifferentdegreeofdifferentiationandprognosiswerecompared.ResultResultTheserumlevelsofmiRNA-4295andmiRNA-34ainobservationgroupwerelowerthanthoseinthecontrolgroup,andthedifferenceswerestatis...
