PCOS诊治进展.pptxVIP免费

多囊卵巢综合症诊治进展PolycysticOvarySyndrome(PCOS)----ProgressinDiagnosisandTherapy浙江大学医学院附属妇产科医院朱小明第一页，共五十五页。授课提纲PCOS概念及相关进展PCOS发病机制及相关进展PCOS诊断标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展第二页，共五十五页。PCOS概念-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism(HA)polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003Rotterdamconsensusworkshop第三页，共五十五页。多囊卵巢综合症的概念-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223第四页，共五十五页。PCOS病理生理特点-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism〔HA〕polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003Rotterdamconsensusworkshop第五页，共五十五页。PCOS病理生理特点-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223第六页，共五十五页。授课提纲PCOS概念及相关进展PCOS发病机制及相关进展PCOS诊断标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展第七页，共五十五页。PCOS发病机制及相关进展未完全说明遗传学背景：相关基因多态性易感性！发育源性：表观遗传修饰/基因调控异常新！内分泌紊乱：下丘脑-垂体-卵巢轴功能/糖脂代谢紊乱经典/主流！第八页，共五十五页。PCOS发病机制及相关进展-遗传学背景方面家族聚集性发现70多种相关基因〔多态性〕，包括：与性激素代谢相关的基因：SHBG基因、CYP11A基因、AR基因等影响胰岛素分泌及肥胖的基因：INS基因、INS-R基因等第九页...