IDSAIDSA：：20222022新版曲霉菌病诊治指南新版曲霉菌病诊治指南PattersonTF,DenningDW,FishmanJA,etal.PracticeGuidelinesfortheDiagnosisandManagementofAspergillosis:2022UpdatebytheInfectiousDiseasesSocietyofAmerica.[J].Clinicalinfectiousdiseases,2022.PattersonTF,DenningDW,FishmanJA,etal.PracticeGuidelinesfortheDiagnosisandManagementofAspergillosis:2022UpdatebytheInfectiousDiseasesSocietyofAmerica.[J].Clinicalinfectiousdiseases,2022.卢永辉卢永辉2022.07.111微信公众号：感染时间步步非烟微信公众号：感染时间步步非烟第一页，共五十一页。21.EstablishinitiallevelofconfidenceStudydesignInitialconfidenceinanestimateofeffectRandomizedtrialsHighconfidenceObservationalstudiesLowconfidence2.ConsiderloweringorraisinglevelofconfidenceReasonsforconsideringloweringorraisingconfidenceLowerifHigherifRiskofbiasInconsistencyIndirectnessImprecisionPublicationbiasLargeeffectDoseresponseAllplausibleconfounding&bias1.Wouldreduceademonstratedeffector2.Wouldsuggestaspuriouseffectifnoeffectwasobserved3.FinallevelofconfidenceratingConfidenceinanestimateofeffectacrossthoseconsiderationsHighModerateLowVerylow1.RatingtheQualityoftheEvidence第二页，共五十一页。32.DeterminantsoftheStrengthofRecommendationQuality(certainty)ofevidenceResourcesandcostPatients’values&preferencesBalancebetweenBenefits,harms,&burdens第三页，共五十一页。4StrongWeak1.Population:Mostpeopleinthissituationwouldwanttherecommendedcourseofactionandonlyasmallproportionwouldnot2.Healthcareworkers:Mostpeopleshouldreceivetherecommendedcourseofaction3.Policymakers:Therecommendationcanbe1.Population:Themajorityofpeopleinthissituationwouldwanttherecommendedcourseofaction,butmanywouldnot2.Healthcareworkers:Bepreparedtohelppeopletomakeadecisionthatisconsistentwiththeirownvalues/decisionaidsandshareddecisionmaking3.Policymakers:Thereisaneedforsubstantialdebate3.ImplicationoftheStrengthofRecommendation第四页，共五十一页。5曲霉菌病是感染曲霉菌引起的一种真菌病，可累及皮肤、黏膜、眼、鼻、支气管、肺、胃肠道、神经系统、骨骼等多器官系统，严重者导致败...
