Deep-vein-thrombosis深静脉血栓.pptxVIP免费

DeepveinthrombosisXiangYuCheng第一页，共四十六页。WhatIsDeepVeinThrombosis?TheearliestcaseofDVTwasdescribedaround600-900BC.Atsomepoint,theincreasedincidenceofDVTinwomenafterchildbirthwasnoticed,andinthelate1700s,apublichealthrecommendationwasissuedtoencouragewomentobreastfeedasameanstopreventthisphenomenon;theDVTwascalled"milkleg",asitwasthoughttoresultfrommilkbuildingupintheleg.第二页，共四十六页。WhatIsDeepVeinThrombosis?Deepveinthrombosis,orDVT,isabloodclotthatformsinaveindeepinthebody.Bloodclotsoccurwhenbloodthickensandclumpstogether.第三页，共四十六页。WhatIsDeepVeinThrombosis?Abloodclotinadeepveincanbreakoffandtravelthroughtheblood.Theemboluscouldtraveltoanarteryinthelungsandblockbloodflow.Thisconditioniscalledpulmonaryembolism,orPE.第四页，共四十六页。EpidemiologyDeepveinthrombosis*DiagnosesofDVTandPEarenotmutuallyexclusive;anestimated78,511patientsreceiveddiagnosesofbothDVTandPE.VTEestimatesincludepatientswithdiagnosesofeitherDVTorPE.第五页，共四十六页。EpidemiologyDeepveinthrombosisAccordingtothemostrecentACCPguidelines,VTEremainsthesecondmostcommoncauseofprotractedhospitalstayandthethirdmostcommoncauseofexcessmortalityamong7millionpatientsdischargedfrom944acutecarehospitalsintheUS.第六页，共四十六页。CausesGermanpathologistRudolfVirchowpostulatedtheinterplayofthreeprocessesresultinginvenousthrombosis,nowknownasVirchow'striad:DeepveinthrombosisInkeepingwithVirchow'sconcept,alterationsofthecoagulationsystemthatinduceahypercoagulablestatealsoconferanincreasedriskofDVT.第七页，共四十六页。CausesGermanpathologistRudolfVirchowpostulatedtheinterplayofthreeprocessesresultinginvenousthrombosis,nowknownasVirchow'striad:Deepveinthrombosis第八页，共四十六页。CausesThebloodflowpatterninthevalvescancausehypoxemia,whichisworsenedbyvenousstasis,activatespathways-onesthatincludehypoxia-induciblefactor-1andearly-growth-responseprotein1.Hypoxia-induciblefactor-1andearly-growth-responseprotein1contributetomonocyteassociationwithendothelialproteins,suchasP-sel...