2022年医学专题—系统性红斑狼疮与感染.pptxVIP免费

LUPUSVsINFECTIONZhaojiuliangDepartmentofRheumatologyPUMCH,Beijing第一页，共三十页。•Q1.WhatarethemostfrequentinfectionsinpatientswithSLE?•Q2WhicharetheclinicalfactorsinvolvedinthedevelopmentofinfectionsinSLE?•Q3HowcantheriskofinfectiouscomplicationsinSLEbereduced?第二页，共三十页。Q1.WhatarethemostfrequentinfectionsinpatientswithSLE?第三页，共三十页。•Infectionisresponsibleforapproximately25%ofalldeathsinpatientswithsystemiclupuserythematosus(SLE)•Themainreasonofhospitalization•Appearstobehighestwithinthefirst5yearsofdiseaseonset第四页，共三十页。InfectioninSLEClinRheumatol,2014.33(1):57-63.第五页，共三十页。CharacteristicsofmajorinfectionsinSLERespiratorytractsUrinarytractsSkinandsofttissuesThetypesofinfectionsthatSLEpatientsdevelopedwerethesameasinthegeneralpopulation第六页，共三十页。•Themostfrequentinfectionsinclude:–Pneumonia,herpeszostervirus,andurinarytractinfectionArthritisCareRes(Hoboken),2015.67(8):1078-85.CharacteristicsofmajorinfectionsinSLE第七页，共三十页。RelativerisksofhospitalizationsLupuscomparedwithgeneralpopulationArthritisCareRes(Hoboken),2015.67(8):1078-85.第八页，共三十页。PathogenofinfectioninSLEGram-negativebacilli,gram-positivecocci,fungalandotherbacterialinfectionsaccountedfor39.85%,31.58%,18.80%and9.77%,respectivelyofnosocomialinfections.第九页，共三十页。Clinicalmanifestationsofinfections•Atypical!!!第十页，共三十页。Mycobacteriumtuberculosis•TheprevalenceofTBinfectioninSLE:5-30%•Characteristics–higherincidencerate–morefrequentextra-pulmonaryinvolvement–moreextensivepulmonaryinvolvement–Highrelapserateeveniftreatedwithprophylacticizoniazid–morecommoninSLErenaltransplantpatientsZandman-Goddard,G.,InfectionsandSLE.Autoimmunity,2009.38(7):473-485.第十一页，共三十页。Mycobacteriumtuberculosis•TBmaypresentasamimickerofvasculitis•TBmaypresentwithskindiseaseposingadiagnosticchallenge•Ahighindexofsuspicionwillallowprompttreatment.•TB.spot–DatainChina第十二页，共三十页。Viralinfections•AcuteviralinfectionsinSLE–CMV...