·综述·DOI:10．3969/j．issn．1001－5256．2023．03．031近红外荧光成像在肝细胞癌肝切除术中的应用段彦亨，安家泽空军军医大学第一附属医院肝胆外科，西安710032通信作者:安家泽，anjiaze68@163．com(OＲCID:0000－0002－5839－4992)摘要:肝细胞癌(HCC)的治疗是以手术为主的综合治疗，肝切除术需要切除原发性肿瘤并最大限度地保留正常肝组织。然而，在临床手术中，肉眼和触诊难以精确识别肿瘤组织及其边界，往往导致切除不足或过度切除。近红外荧光(NIＲF)成像是一种实时、低成本、无创、高灵敏度的成像技术，在引导手术切除肿瘤的应用中得到了广泛的研究。随着荧光成像系统和荧光探针的发展，可以实现术中肿瘤定位和边界确定，使手术更加准确。本文回顾了用于HCC术中导航的各种NIＲF探针的发展，并讨论了这些探针的当前挑战和潜在机遇。关键词:谱学，近红外线;荧光光度测定法;癌，肝细胞;肝切除术基金项目:国家自然科学基金面上项目(81773177)Applicationofnear－infraredfluorescenceimaginginhepatectomyofhepatocellularcarcinomaDUANYanheng，ANJiaze．(DepartmentofHepatobiliarySurgery，TheFirstAffiliatedHospitalofAirForceMedicalUniversity，Xi’an710032，China)Correspondingauthor:ANJiaze，anjiaze68@163．com(OＲCID:0000－0002－5839－4992)Abstract:Multimodalitytherapybasedonsurgeryisthemaintreatmentmethodforhepatocellularcarcinoma(HCC)，andhepatectomyrequirestheremovalofprimarytumorandthepreservationofnormallivertissuetothemaximumextent．Howeverinclinicalsurgery，itisdifficulttoaccuratelyidentifytumortissueanditsboundarywithvisualinspectionandpalpation，whichoftenresultsinunder－resectionorover－resection．Near－infraredfluorescence(NIＲF)imagingisareal－timenoninvasiveimagingtechniquewithlowcostsandhighsensitivity，andextensivestudieshavebeenconductedtoinvestigateitsapplicationinguidingsurgicalresectionoftumors．Withthedevelopmentoffluorescenceimagingsystemandfluorescenceprobe，intraop-erativetumorlocalizationandboundarydeterminationcanberealizedtomakethesurgerymoreaccurate．ThisarticlereviewsthedevelopmentofvariousNIＲFprobesforintraoperativenavigationinHCCanddiscussescurrentchallengesandpotentialop-portunitiesoftheseimagingprobes．Key...
