ARDS患者(huànzhě)的肺复张第一页,共三十九页。ALI/ARDS的定义(dìngyì)ALI急性起病(qǐbìnɡ)胸片对称的侵润影PaO2/FiO2300mmHgPAWP18mmHg或没有左心衰的证据ARDS急性起病胸片对称(duìchèn)的侵润影PaO2/FiO2200mmHgPAWP18mmHg或没有左心衰的证据第二页,共三十九页。ARDS肺部形态学的改变(gǎibiàn)PuybassetL,etal.Regionaldistributionofgasandtissueinacuterespiratorydistresssyndrome.I.Consequencesforlungmorphology.IntensiveCareMed2000;26:857-69.第三页,共三十九页。ARDS肺部形态学的改变(gǎibiàn)ARDS患者健康对照CT平均密度(HU)-25621-6548GattinoniL,etal.Relationshipsbetweenlungcomputedtomographicdensity,gasexchangeandPEEPinacuterespiratoryfailure.Anesthesiology1988;69:824-32.第四页,共三十九页。ARDS肺部形态学的改变(gǎibiàn)PatronitiN,BellaniG,MaggioniE,ManfioA,MarcoraB,PesentiA.Measurementofpulmonaryedemainpatientswithacuterespiratorydistresssyndrome.CritCareMed2005;33:2547-2554第五页,共三十九页。ARDS肺部形态学的改变(gǎibiàn)GATTINONI-3ZONESGattinoniL.JThoracImag1986;1(3):25第六页,共三十九页。ARDS肺部形态学的改变(gǎibiàn)婴儿肺(BABYLUNG)的概念通气的肺仅相当于正常肺的20–30%ARDS患者肺容积的减少并非意味(yìwèi)胸腔内总容积的减少仅仅是实变组织替代了气体GattinoniL,etal.Relationshipsbetweenlungcomputedtomographicdensity,gasexchangeandPEEPinacuterespiratoryfailure.Anesthesiology1988;69:824-32.第七页,共三十九页。气压(qìyā)伤(barotrauma)机械(jīxiè)通气导致肺过度牵张所引起的肺损伤容积伤(volutrauma)NormalratlungsPIP45,5minPIP45,20mins第八页,共三十九页。剪切力损伤(sǔnshāng)(atelectrauma)指由于肺泡反复塌陷和复张所造成(zàochénɡ)的损伤第九页,共三十九页。肺泡塌陷(tāxiàn)时的剪切力损伤驱动(qūdònɡ)压力30cmH2O时通气肺泡与不通气肺泡交界处的剪切力可高达140cmH2O(Mead1970)F=Px(V/V)第十页,共三十九页。ARDS保护性肺通气(tōngqì)策略机械通气时有两个肺损伤(sǔnshāng)区域–肺容积过低可导致剪切力损伤–肺容积过高可导致肺泡过度牵张,引起容积伤FroeseAB,CritCareMed1997;25:906第十一页,共三十九页。肺开放(kāifàng)与ARDSEditorialEditorial...