传染病Viral-hepatitis(1).pptxVIP免费

1ViralhepatitisTianjinMedicalUniversityGeneralHospitalDepartmentofInfectiousDiseases逄崇杰第一页，共九十四页。2难点HBV形态、基因组结构和编码蛋白HBV、HCV的发病机制肝炎的临床分类和临床表现〔慢肝和重肝〕HBV抗原-抗体系统的组成和意义慢性HBV、HCV的治疗HBV的母婴阻断第二页，共九十四页。3重点和问题定义：病毒性肝炎，Dane颗粒，慢性肝炎，窗口期，cccDNA，胆酶别离HBV在人体内的复制过程和发病机制HCV感染易转为慢性的原因HBV抗原-抗体系统的组成和意义各型病毒性肝炎的传播途径病毒性肝炎的临床分类重型肝炎的并发症慢性乙肝、丙肝的药物治疗意外暴露HBV后的预防第三页，共九十四页。4IntroductionViralhepatitisisagroupsystemiccommunicablediseaseaffectingtheliverpredominantlycausedbysomekindsofvirusesViralhepatitismaybedividedinto5typesaccordingtoetiology,thatishepatitisA,B,C,DandEAlthoughtheagentscanbedistinguishedbyitsantigenicproperties,the5kindsofvirusesmayproduceclinicalsimilarillness第四页，共九十四页。5IntroductionClinicalmanifestationsarecharacterizedbyanorexia,nausea,fatigue,enlargedliverandabnormalliverfunction,apartofcasesmayappearjaundice.HepatitisAandEshowsacutehepatitis,fecal-oralroutepredominantlyHepatitisB,CandDpredisposetoachronichepatitisandisrelatedtolivercirrhosisandhepaticcancer,humoraltransmission.第五页，共九十四页。6IntroductionRecently,3kindsofvirusesnamedGBV-C,TTVandSENVarediscovered,andnotyetconsideredtorelatetoviralhepatitis第六页，共九十四页。7Etiology:HepatitisAvirus(HAV)HAVisonekindofpicornavirus〔微小RNA病毒科〕andusedtobeclassifiedasenterovirustype72,butrecently,itisconsideredtobeclassifiedasheparnavirus〔嗜肝RNA病毒属〕HepatitisAvirionisasphericalparticle,diameter27~32nmConsistsofagenomeoflinear,single-strandedRNA,7.5kb第七页，共九十四页。8Etiology:HepatitisAvirus(HAV)Sevengenetypes,1,2,3,4typesfromhumanbodyOnlyoneantigen-antibodysystem.Anti-HAVIgMisdiagnosticevidenceofrecentinfection,IgGisprotectiveantibody.Duringacutestageofinfection,HAVcanbefoundinbloodandfecesofinfectedhuman第八页，共九十四页。9Etiology:H...