(miǎnyì)第一页，共三十一页。Theoralcavityharborsmorethan700bacterialspecies,coexistingwithprobablymillionsofviralgenomiccopies.口腔定居的细菌有700多种与数百万病毒基因组复制(fùzhì)物共存（ATsuoAmano,2010,Periodontology2000）第二页，共三十一页。Oralbacteria口腔中的细菌：--Freetosaliva在唾液(tuòyè)中--Attachmentinbiofilm附着在生物膜BetweencloselyrelatedSalivaasacarrier,isconducivetohorizontalandverticaltransmissionofbacteria第三页，共三十一页。InUnitedStates,75percentofadultpopulationssufferfromperiodontaldisease.美国占75%成年人群体不同(bùtónɡ)程度患有牙周病1/3childrenof6~11yearsold,and2/3ofadolescentpopulationhavesomedegreeofperiodontalproblems.1/3的6~11岁儿童，2/3青春期人群也有某种程度的牙周问题第四页，共三十一页。Over200kindsofbacterialformdentalplaque,adheretothesurfaceoftheteethandgums,andcauseperiodontalinfections.牙周感染(gǎnrǎn)细菌达200余种PeriodontitisⅠGingivitisbleeding，DeepgingivalPocket<3mmⅡPeriodontitisbleeding，swelling，initialboneloss,DeepperiodontalPocket=5mmⅢmajorstagebleeding，swelling，majorboneloss，DeepperiodontalPocket＞6mm第五页，共三十一页。PeriodontalPocket:auniquemicro-environment牙周袋是独特的微环境escapethephysicalseparationforce逃逸物理分离力hardtissuesurface不剥脱更新的硬组织表面junctionalepithelialization,basicallynotdifferentiation有结合上皮，基本上不分化(fēnhuà)non-keratinizingepithelium无角化facultativeanaerobic→anaerobic兼性厌氧→厌氧nutrition,humidity,pH,Eh营养、湿度、pH、Eh第六页，共三十一页。第七页，共三十一页。龈下细菌(xìjūn)附着和聚集模式图RootsurfacePellicleP.gP.gP.gP.gP.g第八页，共三十一页。Subgingivalbiofilmformation龈下生物膜形成Initialcolonization早期(zǎoqī)定居者：actinomyces,streptococcisucceededcolonization微生物交替后：periodontalpathogens致病微生物定植Pg，AA,forsythia,T.denticoleFusobacteriumnucleatum第九页，共三十一页。第十页，共三十一页。1996confirmedthreebacteriaforperiodontalpathogens:Actinobacillusactinomycetemcomitans(AA)Tannerellaforsythia(TF)Porphyromonasgingivali...
