研究通讯Communication*E-mail:huangxiuqing@stu.scu.edu.cnReceivedDecember27,2022;publishedMarch1,2023.SupportinginformationforthisarticleisavailablefreeofchargeviatheInternetathttp://sioc-journal.cn.ActaChim.Sinica2023,81,217—221©2023ShanghaiInstituteofOrganicChemistry,ChineseAcademyofScienceshttp://sioc-journal.cn217化学学报ACTACHIMICASINICA葫芦状有机金属配位笼的合成及其对两种药物分子的选择性结合黄秀清*张琦(四川大学化学学院成都610065)摘要自1998年第一个设计并合成的Pd2L4型配位笼分子被报道以来,Pd2L4型笼被不断深入研究,目前已广泛应用到催化、药物传递、分子识别等领域.本工作介绍了一个葫芦状Pd2L4型有机金属配位笼(C1)的合成,且经核磁共振氢谱(1HNMR)和高分辨质谱(HR-MS)表征,并用1HNMR研究了C1与两种药物分子磺胺胍(G1)和顺铂(G2)的主客体化学行为.1HNMR结果显示C1的两个不同空腔内能够选择性分别结合G1和G2.无论G1和G2是同时加入还是分步加入,都能得到相同的主客体复合物.这一实验结果为后续的靶向给药相关研究奠定了基础,为联合用药提供了新思路.关键词双空腔笼;磺胺胍;顺铂;主客体化学;选择性结合AGourd-shapedOrganometallicCoordinationCage:SynthesisandSelectiveBindingofTwoDrugMoleculesHuang,Xiuqing*Zhang,Qi(CollegeofChemistry,SichuanUniversity,Chengdu610065)AbstractThePd2L4typecoordinationcagehasbeenextensivelystudiedandwidelyappliedincatalysis,drugdelivery,molecularrecognitionandotherresearchfieldssincetheseminalreportin1998.Inthiswork,agourd-shapedPd2L4typecoordinationcage(C1)wassynthesizedandcharacterizedbyprotonnuclearmagneticresonancespectroscopy(1HNMR)andhighresolutionmassspectrum(HR-MS).Thehost-guestchemistryofC1wasstudiedby1HNMRwithtwodrugmolecules,sulfaguanidine(G1)andcisplatin(G2).1HNMRresultsshowthatG1andG2canbeselectivelycombinedintwodifferentcavitiesofC1.Thesamehost-guestcomplexcouldbeobtained,whetherG1andG2wereaddedatthesametimeorinastepwisefashion.Thisworklaidafoundationfordrugdeliveryandprovidedanewinspirationforconcomitantdrugs.Keywordsdoublecavitycage;sulfaguanidine;cisplatin;host-guestchemistry;selectivebonding1引言自然界中无数重要的生物过程中都利用了自组装的结构,受此启发,超分子化学...
