2022年医学专题—神经系统药理—魏尔清-抗癫痫药(1).pptVIP免费

Part9Part9AntiepilepticandAntiepilepticandAnticonvulsantDrugsAnticonvulsantDrugs第一页，共三十四页。PsychomotorseizuresPsychomotorseizuresPetitmal(absence)Petitmal(absence)Grandmal(tonic-clonic)Grandmal(tonic-clonic)Epilepsyisnotasingleentity;itisEpilepsyisnotasingleentity;itisafamilyofdifferentrecurrentafamilyofdifferentrecurrentseizuredisordersthathaveinseizuredisordersthathaveincommonthesudden,excessiveandcommonthesudden,excessiveanddisorderlydischargeofcentraldisorderlydischargeofcentralneurons.neurons.ThisresultsinabnormalThisresultsinabnormalmovementorperceptionsthatmovementorperceptionsthatareofshortdurationbutthatareofshortdurationbutthattendtorecur.tendtorecur.第二页，共三十四页。Generalizedseizures(Generalizedseizures(全身发作全身发作））第三页，共三十四页。第四页，共三十四页。NormalEEGNormalEEGAbsenceEEGAbsenceEEG第五页，共三十四页。ThepathwaysforseizureThepathwaysforseizurepropagationinpartialpropagationinpartialseizuresandprimaryseizuresandprimarygeneralizedseizuresgeneralizedseizures第六页，共三十四页。第七页，共三十四页。StereotypicalcomplexpartialseizuresStereotypicalcomplexpartialseizures第八页，共三十四页。MechanismsofantiepilepticdrugsMechanismsofantiepilepticdrugsElectrophysiologicalElectrophysiologicalInhibitingexcessivedischargesInhibitingexcessivedischargesInhibitingspreadofdischargesInhibitingspreadofdischargesMolecularMolecularPotentiatingGABAneuronalfunctionsPotentiatingGABAneuronalfunctionsModulatingNaModulatingNa++,Ca,Ca2+2+,K,K++channelfuctionschannelfuctions第九页，共三十四页。A.A.AntiepilepticdrugsAntiepilepticdrugsSpecialdrugsSpecialdrugsPhenytoinSodiumPhenytoinSodium苯妥英钠苯妥英钠第十页，共三十四页。1.1.PharmacologicaleffectsandthemechanismPharmacologicaleffectsandthemechanismInhibitinginfluxofNaInhibitinginfluxofNa++andCaandCa2+2+InhibitingspreadofInhibitingspreadofabnormaldischargesabnormaldischargesA.A.AntiepilepticdrugsAntiepilepticdrugs第十一页，共三十四页。第十二页，共三十四页。2.2.ClinicalusesClini...