230脑与神经疾病杂志2023年第31卷第4期nervegrowthandalleviatesneurologicalimpairmentaftercerebralischemia-reperfusioninjuryinaratmodel[J].BiomedPharmacother,2019,111:1447-1457.D01:10.1016/j.biopha.2018.12.067.[25]LuoX,LiL,ZhengW,etal.HLY78protectsblood—brainbarrierintegritythroughWnt/P-cateninsignalingpathwayfollowingsubarachnoidhemorrhageinrats[J].BrainResBull,2020,162:107-114.D01:10.1016/j.brainresbull.2020.06.003.[24]KriskaJ,JaneckovaL,KirdajovaD,etal.Wnt/p-cateninsignalingpromotesdifferentiationofischemia-activatedadultneuralstem/progenitorcellstoneuronalprecursorsfj].FrontNeurosci,2021,15:628983.D01:10.3389/fnins.2021.628983.(收稿日期:2022-07-07)?论著.阿替普酶静脉溶栓联合丁苯酞对急性脑梗死患者出血性转化的影响及神经保护作用机制吕洲朱海生刘青蕊【摘要】目的探讨阿替普酶静脉溶栓联合丁苯酞对急性脑梗死(ACI)患者出血性转化(HT)的影响及其神经保护作用机制。方法将102例具有溶栓条件的ACI随机分为两组:对照组51例接受阿替普酶静脉溶栓和常规对症支持治疗,观察组51例在此基础上加用丁苯酞。比较两组HT发生率,评价NIHSS评分,检测血清炎症因子、氧化应激指标和血管内皮细胞水平变化。结果治疗3d、7d和14d后,观察组的NIHSS评分...