2023年4月第30卷第4期阿替普酶联合银杏叶提取物治疗老年急性缺血性脑卒中的临床效果赵静雅，高洋，周淑芳（河南大学淮河医院神经内科，河南开封475000）【摘要】目的探讨阿替普酶联合银杏叶提取物治疗老年急性缺血性脑卒中（AIS）的效果。方法100例老年AIS患者随机分为两组，对照组采用阿替普酶治疗，观察组采用阿替普酶联合银杏叶提取物治疗，比较两组的治疗效果、日常生活能力、神经功能缺损及神经递质水平。结果观察组的总有效率为94.00%，高于对照组的80.00%（P<0.05）。治疗后，观察组的ADL评分高于对照组，NIHSS评分低于对照组，5-HT、DA水平均高于对照组，Glu水平低于对照组（P<0.05）。结论阿替普酶联合银杏叶提取物治疗老年AIS可改善患者的日常生活能力，减轻神经功能损伤，其机制可能与调节神经递质表达有关。【关键词】阿替普酶；银杏叶提取物；急性缺血性脑卒中中图分类号：R2-031文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0497ClinicalEffectofAlteplaseCombinedwithGinkgoBilobaExtractintheTreatmentofElderlyAcuteIschemicStrokeZHAOJingya,GAOYang,ZHOUShufang(DepartmentofNeurology,HuaiheHospitalofHe'nanUniversity,Kaifeng475000,China)[Abstract]ObjectiveToexploretheclinicaleffectofalteplasecombinedwithGinkgoBilobaextractinthetreatmentofelderlyacuteischemicstroke(AIS).Methods100elderlypatientswithAISwererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithalteplase,andtheobservationgroupwastreatedwithalteplasecombinedwithGinkgoBilobaextract.Thetherapeuticeffect,dailylivingability,neurologicaldeficitandneurotransmitterlevelswerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateoftheobservationgroupwas94.00%,higherthan80.00%ofthecontrolgroup(P<0.05).Aftertreatment,theADLscoreoftheobservationgroupwashigherthanthatofthecontrolgroup,theNIHSSscorewaslowerthanthatofthecontrolgroup,thelevelsof5-HTandDAwerehigherthanthoseofthecontrolgroup,andthelevelofGluwaslowerthanthatofthecontrolgroup(P<0.05).ConclusionsAlteplasecombinedwithGinkgoBilobaextractinthetreatmentofelderlyacuteischemicstrokecanimprovethedailylivingabilityofpatientsandreduceneurologicalimpairment.Themechanismmayberelatedtotheregulationofneurotransmitterex...
