160ContinuingMedicalEducation,February2023,Vol.37,No.2HBsAg(+)供体肾移植HBsAg(-)受体的相关研究进展作者单位:1重庆医科大学第二临床学院,重庆400016;2重庆医科大学附属第二医院泌尿肾病中心,重庆400016▲通信作者:张克勤,E-mail:zhkq2000@sina.com刘晋丞1张克勤2▲【摘要】肾移植已成为肾病终末期患者的首选治疗方法,其进一步的推广与发展仍面临部分问题,供体不足仍是限制肾移植手术开展的重要因素之一。乙肝感染者的肾脏是重要的供体来源,其作为血液传播性疾病,应用乙肝表面抗原阳性供体肾脏可能造成乙肝病毒在供受体之间传播,在部分实验中观察到受体乙肝表面抗原转阳等情况,导致受体术后生存率的减少与生活质量的降低。因此需要在不同供受体情况下选择应用相应个体化的预防与治疗手段,减少病毒传播的风险,以及术后随访的过程中通过对相应指标的监测与随访及时发现潜在的病毒传播情况并采取相应对策,期望将不同供受体的移植情况进行系统性总结,为肾移植围手术期治疗方案提供理论与应用参考。【关键词】肾移植;乙肝病毒;乙肝表面抗原;乙肝核心抗体;供受体;治疗方法【中图分类号】R617【文献标志码】A【文章编号】1004-6763(2023)02-0160-04doi:10.3969/j.issn.1004-6763.2023.02.041ResearchProgressofKidneyTransplantationFromHepatitisBSurfaceAntigenPositiveDonortoHepatitisBSurfaceAntigenNegativeRecipientLIUJincheng1ZHANGKeqin2▲(1TheSecondClinicalCollege,ChongqingMedicalUniversity,Chongqing400016,China;2UrinaryNephropathyCenter,theSecondAffiliatedHospitalofChongqingMedicalUniversity,Chongqing400016,China)[Abstract]Kidneytransplantationhasnowbecomethepreferredtreatmentmethodforpatientswithend-stagerenaldisease,buttherearestillissueswithitspromotionanddevelopment.Oneofthemajorfactorslimitingkidneytransplantoperationsisalackofdonors.HepatitisBpatients'kidneysarevaluablesourceoforgandonors.HepatitisBisablood-borneillness,andthetransplantationofakidneyfromadonorwhohasthevirusmayspreaditfromdonortorecipient.Insomeresearch,therecipient'shepatitisBsurfaceantigenchangestopositivethatreducedtherecipient'slifeexpectancyandqualityoflife.Theriskofvirustransmissionmustthereforebereducedbychoosingandputtingintopracticeindividualizedpreve...