-176-ChineseandForeignMedicalResearchVol.21,No.3January,2023综述Zongshu《中外医学研究》第21卷第3期（总第551期）2023年1月*基金项目：中国抗癌协会淋巴瘤科研基金项目（CORP-117）①内蒙古医科大学鄂尔多斯临床医学院内蒙古鄂尔多斯017000②鄂尔多斯市中心医院通信作者：赛音其木格CXCL12-CXCR4轴在慢性淋巴细胞白血病中的研究进展*苏布敦①赛音其木格②刘希金②王晓茜①【摘要】慢性淋巴细胞白血病（chroniclymphocyticleukemia，CLL）是一种惰性恶性肿瘤，其特征在于成熟但功能失调的B淋巴细胞产生增加。趋化因子受体4（CXCR4）在CLL淋巴细胞上高表达且过与其相应的配体结合促进CLL细胞的动员、迁移、增殖和存活。据最近相关文献报道，趋化因子12-趋化因子受体4（CXCL12-CXCR4）轴通过激活多种信号通路及造血干细胞的迁移和归巢对骨髓中的生态环境进行调节，已成为CLL治疗靶点，尤其CXCR4靶向示踪剂临床上的研究非常活跃。但CXCR4在CLL中作用的相关文献较少。本文就CXCL12-CXCR4轴在CLL中的表达、作用机制、靶向治疗等方面的研究进展做一综述。【关键词】慢性淋巴细胞白血病趋化因子受体4趋化因子12靶向治疗doi：10.14033/j.cnki.cfmr.2023.03.044文献标识码A文章编号1674-6805（2023）03-0176-06ResearchProgressofCXCL12-CXCR4AxisinChronicLymphocyticLeukemia/Subudun,Saiyinqimuge,LIUXijin,WANGXiaoqian.//ChineseandForeignMedicalResearch,2023,21(3):176-181[Abstract]Chroniclymphocyticleukemia(CLL)isanindolentmalignanttumorcharacterizedbyanincreaseintheproductionofmaturebutdysfunctionalBlymphocytes.Chemokinereceptor4(CXCR4)ishighlyexpressedonCLLlymphocytesandoverbindingwithitscorrespondingligandpromotesthemobilization,migration,proliferationandsurvivalofCLLcells.Accordingtorecentreports,chemokine12-chemokinereceptor4(CXCL12-CXCR4)axisregulatestheecologicalenvironmentinbonemarrowbyactivatingvarioussignalingpathwaysandmigrationandhomingofhematopoieticstemcells,andhasbecomeatherapeutictargetofCLL,especiallyCXCR4-targetedtracers,whichareveryactiveinclinicalstudies.However,therearefewliteraturesabouttheroleofCXCR4inCLL.Inthisreview,theexpression,mechanismandtargetedtherapyofCXCL12-CXCR4axisinCLLwerereviewed.[Keywords]ChroniclymphocyticleukemiaChemokinerecept...
