〔2〕FylesG,MessnerHA,MindenMD,etal.Cyclosporineainthetreat⁃mentofacutegraft⁃versus⁃hostdisease〔J〕.StemCells,2010,4(S1):200⁃202.〔3〕McdonaldGB,SlatteryJT,BouvierME,etal.Cyclophosphamideme⁃tabolism,livertoxicity,andmortalityfollowinghematopoieticstemcelltransplantation〔J〕.Blood,2003,101(5):2043.〔4〕COGStemCellCommitteeConsensusGuidelinesforEstablishingOr⁃ganStageandOverallGradeofAcuteGraftVersusHostDisease(GVHD),CitedinChildren′sOncologyGroupprotocolASCT0431.StudyChair:MichaelA.Pulsipher,MD2011.〔5〕MalardF,SzydloRM,BrissotE,etal.ImpactofCyclosporine⁃ACon⁃centrationontheIncidenceofSevereAcuteGraft⁃versus⁃HostDiseaseafterAllogeneicStemCellTransplantation〔J〕.BiologyofBlood&MarrowTransplantationJournaloftheAmericanSocietyforBlood&MarrowTransplantation,2010,16(1):28⁃34.〔6〕OshimaK,KandaY,NakasoneH,etal.Decreasedincidenceofacutegraft⁃versus⁃hostdiseasebycontinuousinfusionofcyclosporinewithahighertargetbloodlevel〔J〕.AmericanJournalofHematology,2008,83(3):226⁃32.〔7〕ZeighamiS,HadjibabaieM,AshouriA,etal.Asse...