有机化学ChineseJournalofOrganicChemistryREVIEW*Correspondingauthors.E-mail:chenyj@zzu.edu.cn;yanglh@zzu.edu.cnReceivedJuly13,2022;revisedAugust8,2022;publishedonlineSeptember15,2022.ProjectsupportedbytheNaturalScienceFoundationofHenanProvince(No.212300410152)andtheHenanUniversityofAnimalHusbandryandEconomy(Nos.2019HNUAHEDF011,XKYCXJJ2020006).河南省自然科学基金(No.212300410152)和河南牧业经济学院(Nos.2019HNUAHEDF011,XKYCXJJ2020006)资助项目.†共同第一作者(Theseauthorscontributedequallytothiswork).74http://sioc-journal.cn/©2023ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciencesChin.J.Org.Chem.2023,43,74～93DOI:10.6023/cjoc202207022综述与进展N-Ts氰胺在有机合成中的研究与应用王川川†,a马志伟†,a侯学会a杨龙华*,b陈亚静*,b(a河南牧业经济学院理学部郑州450052)(b郑州大学药学院郑州450001)摘要N-Ts氰胺是有机合成中非常高效和实用的一种多功能合成前体,其在构建含氮骨架领域中获得了较多应用.根据反应类型划分,总结了近年来N-Ts氰胺在有机合成中的研究进展,主要包括其在氰基化反应、经氰胺负离子参与的环化反应、氰胺化反应、磺酰化反应及经氰基官能团参与的环化反应等方面的应用,并对该领域的研究前景进行了展望.关键词N-Ts氰胺;氰基化;氰胺化;磺酰化;环化反应ResearchandApplicationofN-TsCyanamidesinOrganicSynthesisWang,Chuanchuan†,aMa,Zhiwei†,aHou,XuehuiaYang,Longhua*,bChen,Yajing*,b(aFacultyofScience,HenanUniversityofAnimalHusbandryandEconomy,Zhengzhou450046)(bSchoolofPharmaceuticalSciences,ZhengzhouUniversity,Zhengzhou450001)AbstractN-Tscyanamide,whichhasbeenwidelyusedintheconstructionofnitrogen-containingframework,isoneoftheefficientandpracticalmultifunctionalsyntheticprecursorsinorganicsynthesis.TheprogressinapplicationofN-Tscyanamideaccordingtothereactiontypesissummarized,includingtheapplicationincyanation,cyclizationreactionviacyanamideani-on,cyanamidation,sulfonylationandcyclizationreactionviacyano-group.Thefuturedevelopmentdirectionofthisfieldisalsoprospected.KeywordsN-Tscyanamides;cyanation;cyanamidation;sulfonylation;cyclizationreactionsN-Ts氰胺(N-对甲苯磺酰基氰胺,Scheme1)于1949年被首次合...
