_STP_1408-2002.pdf

STP 1408 Isocyanates:Sampling,Analysis,and Health Effects Jacques Lesage,Irene DeGraff,and Richard Danchik,editors ASTM Stock Number:STP1408 INTERNA nONAL ASTM 100 Barr Harbor Drive PO Box C700 West Conshohocken,PA 19428-2959 Printed in the U.S.A.Library of Congress Cataloging-in-Publication Data Isocyanates:sampling,analysis,and health effects/Jacques Lesage,Irene DeGraff,and Richard Danchik,editors.p.cm.-(STP;1408)ASTM Stock Number:STPI408.Contains papers presented at a symposium.Includes bibliographical references and index.ISBN 0-8031-2879-7 l.Isocyanates-Toxicology-Congresses.2.Isocyanates-Environmental aspects-Congresses.3.Isocyanates-Analysis-Congresses.4.Environmental sampling-Congresses.I.Lesage,Jacques,t958-II.DeGraff,Irene,1948-III.Danchik,Richard,1943-IV.ASTM special technical publication;1408.RA1247.M45 184 2001 615.95142dc21 2001056056 Copyright?9 2001 ASTM International,West Conshohocken,PA.All rights reserved.This material may not be reproduced or copied,in whole or in part,in any printed,mechanical,electronic,film,or other distribution and storage media,without the written consent of the publisher.Photocopy Rights Authorization to photocopy items for internal,personal,or educational classroom use,or the internal,personal,or educational classroom use of specific clients,is granted by ASTM International provided that the appropriate fee is paid to the Copyright Clearance Center,222 Rosewood Drive,Danvers,MA 01923;Tel:978-750-8400;online:http:/ Review Policy Each paper published in this volume was evaluated by two peer reviewers and at least one edi-tor.The authors addressed all of the reviewers comments to the satisfaction of both the technical editor(s)and the ASTM Committee on Publications.To make technical information available as quickly as possible,the peer-reviewed papers in this publication were prepared camera-ready as submitted by the authors.The quality of the papers in this publication reflects not only the obvious efforts of the authors and the technical editor(s),but also the work of the peer reviewers.In keeping with long-standing publication practices,ASTM International maintains the anonymity of the peer reviewers.The ASTM Committee on Publications acknowledges with appreciation their dedication and contribution of time and effort on behalf of ASTM International.Printed in Saline,MI 2002 Foreword This publication,lsocyanates:Sampling,Analysis,and Health Effects,contains papers presented at the symposium of the same name held in Orlando,Florida,on October 26-27,2000.The symposium was sponsored by ASTM Committee D22 on Sampling and Analysis of Atmospheres,and its Subcommittee D22.04 on Workplace Atmospheres,in cooperation with IRSST(Institut de recherch6 en sante et en securite du travail du Quebec).The sym-posium co-chairs were Irene D.DeGraff,Supelco,Bellefonte,Pennsylvania,USA and Jacques Lesage,IRSST,Montreal,Quebec,Canada.Contents Isocyanate Measurement Methods-ISO Standardization-RiCHARD H.BROWN Analysis of Isocyanates with LC-MS/MS-ANDERS OSTIN,MARGIT SUNDGREN,JENNY EKMAN,ROGER LINDAHL,AND JAN-OLOF LEVIN Laboratory Comparison of Sampling Methods for Reactive Isocyanate Vapors and AerosolsRoY J.RANDO,HALET G.POOVEY,AND DINKAR R.MOKADAM Work-Related Asthma from Exposure to Isocyanate Levels Below the Michigan OSHA Permissible Exposure LimitMARV JO REmLY,KENNETH D.ROSENMAN,AND JOHN H.PECK Isocyanate Exposures in the United KingdomJOHN J.McALINDEN Some Limitations in the Use of Urine Biomonitoring for Measuring TDI ExposuFeANNE HARMAN CHAPPELLE,RONALD N.SHIOTSUKA,AND MICHAEL J.BARTELS Patch Testing for IsoeyanateSmATHENA T.JOLLY,DIETER BRAMANN,AND HANS-PETER HOFFARTH Antibody Testing:Analysis of the Specificity of Antibody Detection in a Non-Diisocyanate-Exposed PopulationmWILLIAM E.BROWN,SHEREEN GAMALUDDIN,AND AMY L.KENNEDY Field Evaluation of a Gravimetric Sampling Method as a Screening Tool for the Monitoring of Airborne Isocyanates in Paint-Spray Operations-WM.WESLEY NORTON AND VENKATRAM DHARMARAJAN Workplace TRIG and Air-Purifying Respiratory Protection-HALET G.POOVEY AND ROY J.RANDO Use of Air-Purifying Respirators for Substances with Limited or Poor Warning Properties-STEFANIE M.CORBITT,E.A.HEGER,AND DAVID G.SARVADI 12 21 38 54 64 75 80 94 110 123 Richard H.Brown L Isocyanate Measurement Methods-ISO Standardization Reference:Brown,R.H.,Isocyanate Measurement Methods-ISO Standardization,Isocyanates:Sampling,Analysis and Health Effects,ASTM STP 1408,J.Lesage,I.D.DeGraff,and R.S.Danchik,Eds.,American Society for Testing and Materials,West Conshohocken,PA,2002.Abstract:Historically,a large number of alternative methods have been devised for the measurement of airborne isocyanates.Nearly all these methods rely on the derivatization of the reactive isocyanate groups to products that can be analyzed,usually by some form of chromatography.The choice of an ideal method relies partly on the requirements of the regulatory authorities,but there are also technical considerations co