Designation:E1372–95(Reapproved2003)StandardTestMethodforConductinga90-DayOralToxicityStudyinRats1ThisstandardisissuedunderthefixeddesignationE1372;thenumberimmediatelyfollowingthedesignationindicatestheyearoforiginaladoptionor,inthecaseofrevision,theyearoflastrevision.Anumberinparenthesesindicatestheyearoflastreapproval.Asuperscriptepsilon(e)indicatesaneditorialchangesincethelastrevisionorreapproval.1.Scope1.1Thistestmethodhasbeendesignedtoexaminethesubchronicoraltoxicityofatestsubstanceduringa90-dayperiodofcontinuousoralexposuretorats(Rattusnorvegicus)followinginitialacutetoxicitytests.1.2ThevaluesstatedinSIunitsaretoberegardedasthestandard.Thevaluesgiveninparenthesesareforinformationonly.1.3Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappro-priatesafetyandhealthpracticesanddeterminetheapplica-bilityofregulatorylimitationspriortouse.2.ReferencedDocuments2.1ASTMStandards:E609DefinitionsofTermsRelatingtoPesticides2E1163TestMethodforEstimatingAcuteOralToxicityinRats22.2FederalStandards:Title40,CodeofFederalRegulations(CFR),Environmen-talProtectionAgency,Part798,HealthEffectsTestingGuidelines,SubpartC,SubchronicExposure,OralToxic-ity3Title40,CodeofFederalRegulations(CFR),Environmen-talProtectionAgency,Part798,HealthEffectsTestingGuidelines,SubpartB,GeneralToxicityTesting,AcuteOralToxicity3Title40,CodeofFederalRegulations(CFR),Environmen-talProtectionAgency,SubchapterE,PesticidePrograms;Part160,GoodLaboratoryPracticeStandards3Title21,CodeofFederalRegulations(CFR),FoodandDrugAdministration,Part58,GoodLaboratoryPracticeforNonclinicalLaboratoryStudies3Title40,CodeofFederalRegulations(CFR),ToxicSub-stanceControlAct,Part792,GoodLaboratoryPracticeStandards33.Terminology(seeDefinitionsE609)3.1Definitions:3.1.1concentration—Theweightofthetestsubstanceperunitweightofthediet(expressedasmg/kgofdiet).TheweightofthetestsubstancepervolumeofH2O(expressedasmg/mlofH2O),orataconstantratei...
