Designation:E1847−96(Reapproved2013)StandardPracticeforStatisticalAnalysisofToxicityTestsConductedUnderASTMGuidelines1ThisstandardisissuedunderthefixeddesignationE1847;thenumberimmediatelyfollowingthedesignationindicatestheyearoforiginaladoptionor,inthecaseofrevision,theyearoflastrevision.Anumberinparenthesesindicatestheyearoflastreapproval.Asuperscriptepsilon(´)indicatesaneditorialchangesincethelastrevisionorreapproval.1.Scope1.1Thispracticecoversguidanceforthestatisticalanalysisoflaboratorydataonthetoxicityofchemicalsormixturesofchemicalstoaquaticorterrestrialplantsandanimals.Thispracticeappliesonlytotheanalysisofthedata,afterthetesthasbeencompleted.Alldesignconcerns,suchasthestatementofthenullhypothesisanditsalternative,thechoiceofalphaandbetarisks,theidentificationofexperimentalunits,possiblepseudoreplication,randomizationtechniques,andtheexecu-tionofthetestarebeyondthescopeofthispractice.Thispracticeisnotatextbook,nordoesitreplaceconsultationwithastatistician.Itassumesthattheinvestigatorrecognizesthestructureofhisexperimentaldesign,hasidentifiedtheexperi-mentalunitsthatwereused,andunderstandshowthetestwasconducted.Giventhisinformation,theproperstatisticalanaly-sescanbedeterminedforthedata.1.1.1Recognizingthatstatisticsisaprofessioninwhichresearchcontinuesinordertoimprovemethodsforperformingtheanalysisofscientificdata,theuseofstatisticalmethodsotherthanthosedescribedinthispracticeisacceptableaslongastheyareproperlydocumentedandscientificallydefensible.Additionalannexesmaybedevelopedinthefuturetoreflectcommentsandneedsidentifiedbyusers,suchasmoredetaileddiscussionofprobitandlogisticregressionmodels,orstatisti-calmethodsfordoseresponseandriskassessment.1.2Thesectionsofthisguideappearasfollows:TitleSectionReferencedDocuments2Terminology3SignificanceandUse4StatisticalMethods5FlowChart6FlowChartComments7Keywords8References1.3Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablis...
