神经系统药理—魏尔清-抗癫痫药.pptVIP免费

Part9Part9AntiepilepticandAntiepilepticandAnticonvulsantDrugsAnticonvulsantDrugsPsychomotorseizuresPsychomotorseizuresPetitmal(absence)Petitmal(absence)Grandmal(tonic-clonic)Grandmal(tonic-clonic)EpilepsyisnotasingleEpilepsyisnotasingleentity;itisafamilyofentity;itisafamilyofdifferentrecurrentseizuredifferentrecurrentseizuredisordersthathaveindisordersthathaveincommonthesudden,commonthesudden,excessiveanddisorderlyexcessiveanddisorderlydischargeofcentralneurons.dischargeofcentralneurons.ThisresultsinabnormalThisresultsinabnormalmovementorperceptionsmovementorperceptionsthatareofshortdurationbutthatareofshortdurationbutthattendtorecur.thattendtorecur.Classificationofepilepsy(older)Classificationofepilepsy(older)Generalizedseizures(Generalizedseizures(全身发作全身发作））GrandmalGrandmal（（大发作大发作）：）：tonic-clonicseizurestonic-clonicseizures（（强直－阵挛强直－阵挛））PetitmalPetitmal（（小发作小发作）：）：absenceseizuresabsenceseizures（（失神发作失神发作））Partialseizures(Partialseizures(部分性发作部分性发作))PshychomotorPshychomotor（（精神运动性精神运动性）：）：temporallobeseizurestemporallobeseizures（（颞叶癫痫颞叶癫痫））PartialPartial（（部分发作部分发作）：）：motor,sensory,ANS,motor,sensory,ANS,etc.etc.（（局限性发作局限性发作））ClassificationofepilepsyClassificationofepilepsyNormalEEGNormalEEGAbsenceEEGAbsenceEEGThepathwaysforThepathwaysforseizurepropagationinseizurepropagationinpartialseizuresandpartialseizuresandprimarygeneralizedprimarygeneralizedseizuresseizuresStereotypicalcomplexpartialseizuresStereotypicalcomplexpartialseizuresMechanismsofantiepilepticdrugsMechanismsofantiepilepticdrugsElectrophysiologicalElectrophysiologicalInhibitingexcessivedischargesInhibitingexcessivedischargesInhibitingspreadofdischargesInhibitingspreadofdischargesMolecularMolecularPotentiatingGABAneuronalfunctionsPotentiatingGABAneuronalfunctionsModulatingNaModulatingNa++,Ca,Ca2+2+,K,K++channelfuctionschannelfuctionsA.A.Antiepile...