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零电位阈电位静息电位动作电位细胞膜+_+_+_+_+_+_+_+_+_+_+_+_+_+_+_+__+Na+,K+-ATPaseATPNa+K+Ca++Cl-Na+K+K+¿çĤµçλmv-100-80-60-40-200+20¸´¼«»¯È¥¼«»¯43210-------NHCHCH2NCH3OHHOH12356781'2'3'4'5'6'7'8'49NHCHCH2NCH3OOHHH¿üÄᶡQuinidine(+)8S:9S¿üÄþQuinine(-)8S:9R948'7'6'5'4'3'2'1'8765321NHCHCH2NCH3OHHOHNHCHCH2NCH3OHHOHHO12356781'2'3'4'5'6'7'8'49NHCHCH2NCH3OHHOHOH12356781'2'3'4'5'6'7'8'49NHCHCH2NHOHHOH12356781'2'3'4'5'6'7'8'49NHHOCH2CH2NCH3OHHOH12356781'2'3'4'5'6'7'8'49ÆÕ³¿¨ÒòProcaineH2NCNHCH2CH2N(C2H5)2OH2NCOCH2CH2N(C2H5)2OÆÕ³¿¨Òò°·ProcainamideCH3CONHCNHCH2CH2N(C2H5)2OÒÒõ£¿¨ÄáAcecainide°¢ÒåÂíÁÖAjmalineCCH2CH2NH2NCONCH(CH3)2CH(CH3)2±ûßÁ°·DisopyramideNNOHC2H5OHCH3ßÁÃÀŵPirmenolÎ÷±½ßòÁÖCibenzolineNNHOHCH2CH2CH2NH3CH3CR药名NHCOCH2N(C2H5)2利多卡因LidocaineNHCOCH(CH3)NH2妥卡胺TocainideOCH2CH(CH3)NH2美西律MexiletineNHCONH(CH2)3NHCH(CH3)2瑞卡南RecainamNHCOCH2N+(CH3)(C2H5)2.Cl-甲基利多卡因MethyllidocaineCH3RCH3神经细胞膜稳定作用ĪÀ×Î÷àºMoricizineNSCOCH2CH2NNHCOOC2H5OIB、IC类抗心律失常作用，扩张冠脉，解痉·ú¿¨ÄáFlecainide¶÷¿¨ÄáEncainideNHCOCH2CH2OCH3NCH3NHCH2NHCOOCH2CF3OCH2CF3Ó¢µØ¿¨ÄáIndecainideÀÍ¿¨ÄáLorcainideClNNCOCH2CH(CH3)2H2NOC(CH2)3NHCH(CH3)2³£¿©ßøPyrozolinÆÕÂÞÅÁͪPropafenoneCOCH2CH2OCH2CHCH2NH(CH2)2CH3OHNNNHOHCH2CH2NNÒÒõ£¿¨ÄáAcecainide°·µâͪAmiodaroneCONHCH2CH2N(C2H5)2CH3CONHOCOOCH2CH2N(CH2)3CH3C2H5C2H5ÃÀßß¡Melperone¼×Ñõ±½Í¡MeobentineFCOCH2CH2CH2NCH3CH2NHCCH3ONNHCH3CH3äåÜа·BretyliumtosylateCH2N+CH2CH3CH3CH3BrCH3SO3-选择性作用于心肌钾离子通道，致心律失常副作用较小抗高血压药物的作用部位和机理紧张脑神经节肾脏心输出量增加血流量增加血管收缩肾素血管紧张素I血管紧张素II醛固酮增大血容积高血压外周阻力增加发病机制发病机制皮层下神经中枢功能变化神经递质浓度与活性异常交感神经系统活性亢进血浆儿茶酚胺浓度升高小动脉阻力增加高血压高血压各种病因各种病因肾性水钠潴留为避免组织过度灌注机体代偿小动脉阻力增加高血压高血压血管紧...