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AcuteCoronarySyndromesEvaluationandRiskStratificationNewTerminologyinACSACS,acutecoronarysyndrome;MI,myocardialinfarction;UA,unstableangina;NSTEMI,non–ST-segmentelevationmyocardialinfarction;STEMI,ST-segmentelevationmyocardialinfarction;PCI,percutaneouscoronaryintervention.CannonCP.JThrombThrombolysis.1995;2:205-218.AntithromboticTherapyStableAnginaUnstableAnginaNon–Q-waveMIThrombolysisPrimaryPCIQ-waveMIMinutes-hoursDays-weeksSTEMIUA/NSTEMIAtherothrombosisNewtermOldtermPlaqueRuptureTroponinI(TnI),C-ReactiveProtein(CRP),andB-typeNatriureticPeptide(BNP)asDeterminantsof30-DayMortalityRisksinAcuteCoronaryIschemia:AMultimarkerApproachOPUS-TIMI1611.83.5601234560123No.ofElevatedBiomarkers30-DayMortalityRelativeRiskP=.014P<.001671501557850471732490SabatineM,etal.Circulation.2002;105:1760-1763.(withpermission)ProgressivemechanicalobstructionSecondaryUA(MVO2)Inflammation/infectionDynamicobstructionNonocclusivethrombusonpre-existingplaqueBraunwaldE.Circulation.1998;98:2219-2222.BraunwaldEtiologicClassificationofUAGUSTOIIb:Correlationof6-MonthMortalityWithBaselineECGFindingsinPatientsWithACSCumulativeMortality(%)02468100306090120150180DaysFromRandomizationT-waveinversionSTACSSTEMIwithfibrinolyticsGUSTO,GlobalUseofStrategiesToOpenOccludedArteriesinAcuteCoronarySyndromes;ECG,electrocardiogram;ACS,acutecoronarysyndrome;STEMI,ST-segmentelevationmyocardialinfarction.SavonittoS,etal.JAMA.1999;281:707-713.(withpermission)TIMI,thrombosisinmyocardialinfarction;UA,unstableangina;NSTEMI,non–ST-segmentelevationmyocardialinfarction;CAD,coronaryarterydisease.AntmanEM,etal.JAMA.2000;284:835-842.TIMIRiskScoreforUA/NSTEMI:7IndependentPredictors•Aged≥65years•≥3CADriskfactors•PriorCAD(stenosis>50%)•Aspirininlast7days•>2anginaleventsin≤24hours•STdeviation•Elevatedcardiacmarkers(CK-MBortroponin)TIMIRiskScoreForUA/NSTEMIAntmanEM,etal.JAMA.2000;284:835-442.(withpermission)•Age>65years•>3CADRiskFactors•PriorStenosis>50%•STdeviation•>2Anginalevents<24hours•ASAinlast7days•Elev...