PCOS诊治进展.pptVIP免费

多囊卵巢综合症诊治进展PolycysticOvarySyndrome(PCOS)----ProgressinDiagnosisandTherapy浙江大学医学院附属妇产科医院朱小明授课提纲PCOS概念及相关进展PCOS发病机制及相关进展PCOS诊断标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展PCOS概念-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism(HA)polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003Rotterdamconsensusworkshop多囊卵巢综合症的概念-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223PCOS病理生理特点-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism（HA）polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003RotterdamconsensusworkshopPCOS病理生理特点-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223授课提纲PCOS概念及相关进展PCOS发病机制及相关进展PCOS诊断标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展PCOS发病机制及相关进展未完全阐明遗传学背景：相关基因多态性易感性！发育源性：表观遗传修饰/基因调控异常新！内分泌紊乱：下丘脑-垂体-卵巢轴功能/糖脂代谢紊乱经典/主流！PCOS发病机制及相关进展-遗传学背景方面家族聚集性发现70多种相关基因（多态性），包括：与性激素代谢相关的基因：SHBG基因、CYP11A基因、AR基因等影响胰岛素分泌及肥胖的基因：INS基因、INS-R基因等PCOS发病机制及相关进展-发育源性学说PCOS糖尿病心血管病……宫内发育宫内发育受精后6w受精后6w配子形成——受精——着床配子形成——受精——着床分娩分娩成年成年“胎儿源性成人疾...