•研究论文•doi:10.16801/j.issn.1008-7303.2022.0106桧木醇衍生物的合成及抑菌活性桂阔,叶久辉,李璇,周海玉,李婕宁,冯俊涛,雷鹏,高艳清*,马志卿(西北农林科技大学植物保护学院，陕西省生物农药工程技术研究中心，陕西杨凌712100)摘要：桧木醇是具有䓬酚酮骨架的单萜类天然化合物,设计并合成了17个新型桧木醇衍生物,其结构经核磁共振波谱及高分辨质谱分析确证。抑菌活性测定结果表明，目标化合物在50μg/mL下对水稻纹枯病菌Rhizoctoniasolani、番茄灰霉病菌Botrytiscinerea、油菜菌核病菌Sclerotiniasclerotiorum、苹果树腐烂病菌Valsamali和黄瓜炭疽病菌Colletotrichumorbiculare均表现出较好的抑菌活性，其中化合物3a对水稻纹枯病菌、3j对番茄灰霉病菌、3m对油菜菌核病菌的EC50值分别为1.84、2.47和1.05μg/mL，表现出比桧木醇(2.00、11.3和5.40μg/mL)更优的活性。关键词:桧木醇；水稻纹枯病菌；番茄灰霉病菌；油菜菌核病菌；抑菌活性中图分类号：TQ450.1；TQ455文献标志码：ASynthesisandantifungalactivityofhinokitiolderivativesGUIKuo,YEJiuhui,LIXuan,ZHOUHaiyu,LIJiening,FENGJuntao,LEIPeng,GAOYanqing*,MAZhiqing(CollegeofPlantProtection,NorthwestA&FUniversity,ShaanxiResearchCenterofBiopesticideEngineering&Technology,Yangling712100,ShaanxiProvince,China)Abstract:Seventeennovelderivativesofhinokitiol,amonoterpenewithatroponoideskeleton,weredesignedandsynthesized.TheirstructureswereconfirmedbyNMRandHRMS.TheinvitrobioassayresultsshowedthatthetargetcompoundsdisplayedsatisfactoryantifungalactivitiesagainstRhizoctoniasolani,Botrytiscinerea,Sclerotiniasclerotiorum,ValsamaliandColletotrichumorbiculareat50μg/mL.Notably,compound3ashowedfavorableactivityagainstR.solani(EC50=1.84μg/mL),3jexhibitedsatisfiedactivityagainstB.cinerea(EC50=2.47μg/mL),and3mexertedexcellentactivityagainstS.sclerotiorum(EC50=1.05μg/mL),whicharebetterthanhinokitiol(2.00,11.3and5.40μg/mL).Keywords:hinokitiol;antifungalactivity;Rhizoctoniasolani;Botrytiscinerea;Sclerotiniasclerotiorum收稿日期：2022-06-13；录用日期：2022-08-10；网络首发日期：2022-09-22.Received:June13,2022;Accepted:August10,2022;Publishedonline:September22,2022.URL:https://doi.org/10.16801/j.issn.1008-73...
