2023年2月第30卷第2期复方甘草酸苷联合替诺福韦酯治疗HBeAg阳性慢性乙型肝炎的效果观察徐前进1，吴秀霞2（河南省中医院1药学部，2肝胆脾胃病科，河南郑州450003）【摘要】目的观察复方甘草酸苷联合替诺福韦酯治疗HBeAg阳性慢性乙型肝炎的效果。方法124例HBeAg阳性慢性乙型肝炎患者随机分为两组，对照组给予替诺福韦酯治疗，观察组给予复方甘草酸苷联合替诺福韦酯治疗，比较两组的肝功能指标以及HBVDNA、HBeAg转阴率。结果治疗后，观察组的血清ALT、AST、TBIL水平均显著低于对照组，HBVDNA转阴率显著高于对照组（P＜0．05）；两组的HBeAg转阴率、不良反应发生率比较，差异无统计学意义（P＞0．05）。结论复方甘草酸苷联合替诺福韦酯治疗HBeAg阳性慢性乙型肝炎效果显著，可有效降低血清HBVDNA水平，促进肝功能改善，且安全性较高。【关键词】复方甘草酸苷；替诺福韦酯；HBeAg阳性慢性乙型肝炎；疗效；肝功能中图分类号：R512.6+2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0181ObservationontheEffectofCompoundGlycyrrhizinCombinedwithTenofovirDipivoxilintheTreatmentofHBeAgPosi-tiveChronicHepatitisB//XUQianjin1,WUXiuxia2(1DepartmentofPharmacy,2DepartmentofHepatobiliary,Spleen,andStomachDiseases,He'nanProvincialHospitalofTraditionalChineseMedicine,Zhengzhou450003,China)[Abstract]ObjectiveToobservetheeffectofcompoundglycyrrhizincombinedwithtenofovirdipivoxilinthetreatmentofHBeAgpositivechronichepatitisB.Methods124patientswithHBeAgpositivechronichepatitisBwererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithtenofovirdipivoxil,andtheobservationgroupwastreatedwithcompoundglycyrrhizincombinedwithtenofovirdipivoxil.Theliverfunctionindicators,andnegativeconversionratesofHBVDNAandHBeAgwerecomparedbetweenthetwogroups.ResultsAftertreatment,thelevelsofserumALT,ASTandTBILintheobservationgroupweresignificantlylowerthanthoseinthecontrolgroup,andthenegativeconversionrateofHBVDNAwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).NosignificantdifferencewasfoundinthenegativeconversionrateofHBeAgandtheincidenceofadversereactionsbetweenthetwogroups(P>0.05).ConclusionsCompoundglycyrrhizincombinedwithtenofovirdipivoxilinthetreatmentofHBeAgpo...
