临床医学研究与实践2023年3月第8卷第7期Effectsofmetformincombinedwithinsulinaspartateonbloodglucosemetabolism,renalinjuryandpregnancyoutcomeofpatientswithgestationaldiabetesmellitusZHAOYun1,ZHAOKe2(1.GynecologyandObstetricsDepartment,DanchengCountyCentralHospital,Zhoukou477150;2.GynecologyandObstetricsDepartment,ZhoukouCentralHospital,Zhoukou466000,China)ABSTRACT:ObjectiveToinvestigatetheeffectsofmetformincombinedwithinsulinaspartateonbloodglucosemetabolism,renalinjuryandpregnancyoutcomeofpatientswithgestationaldiabetesmellitus.MethodsSixtypatientswithgestationaldiabetesmellitusweredividedintocontrolgroupandobservationgroupaccordingtothedifferenttreatmentmethods,with30casesineachgroup.Thecontrolgroupwastreatedwithinsulinaspartate,andtheobservationgroupwastreatedwithmetforminonthebasisofthecontrolgroup.Thetherapeuticeffectsofthetwogroupswerecompared.ResultsAftertreatment,thelevelsofbloodglucosemetabolismindexes[fastingplasmaglucose(FPG),fastinginsulin(FINS),24hmeanamplitudeofglycemicexcursions(MAGE)andmeanofdailydifferences(MODD)],renalinjuryindexes[urinemicroabuminuria(mAlb)andserumcystatinC(CysC),freefattyacid(FFA)andneutrophilgelatinase-associatedlipocalin(NGAL)]andinflammatoryindexes[interleukin-6(IL-6),transforminggrowthfactor-β1(TGF-β1)andlipoproteinassociatedphospholipaseA2(Lp-PLA2)]intheobservationgroupwerelowerthanthoseinthecontrolgroup(P<0.05).Thetotalincidencesofadversepregnancyoutcomesinnewbornsandparturientsintheobservationgroupwaslowerthanthatinthecontrolgroup(P<0.05).ConclusionMetformincombinedwithinsulinaspartateinthetreatmentofgestationaldiabetesmellituscanreducethelevelofbloodglucoseofpatients,reducerenalinjury,andoptimizepregnancyoutcomes.KEYWORDS:metformin;insulinaspartate;gestationaldiabetesmellitus;bloodglucosemetabolism;renalinjury;pregnancyoutcome二甲双胍联合门冬胰岛素对妊娠期糖尿病患者血糖代谢、肾损伤及妊娠结局的影响赵允1，赵可2（1.郸城县中心医院妇产科，河南周口，477150；2.周口市中心医院妇产科，河南周口，466000）摘要：目的探讨二甲双胍联合...
