碘难治性甲状腺癌颈部淋巴结转移灶的局部治疗进展陆路,蒋泽文,赵守松,牟兴宇,付巍(桂林医学院附属医院核医学科,广西桂林541001)DOI:10.11748/bjmy.issn.1006-1703.2022.11.033收稿日期:2022-10-31;修回日期:2022-11-08基金项目:桂林医学院附属医院教职工科研能力提升项目(编号:2019GLMU1A009)通讯作者:付巍(1970一),男,教授,主任医师。研究方向:核素显像与治疗。E-mail:13977385850@126.com摘要:绝大多数的分化型甲状腺癌患者经过手术、131I治疗和TSH抑制治疗后预后良好,但仍有部分患者发生区域淋巴结或远处转移,最常见的就是颈部淋巴结转移,且部分颈部淋巴结转移灶在初始或治疗过程中出现失分化现象,发展成为碘难治性甲状腺癌。碘难治性甲状腺癌严重影响患者的预后及生存率,成为临床诊治的难点和重点。本文对碘难治性甲状腺癌患者的颈部淋巴结转移灶诊断及局部治疗进展进行综述。关键词:甲状腺癌;颈部淋巴结;碘难治;局部治疗中图分类号:R392-33文献标识码:ATheProgressinLocalTreatmentofCervicalLymphNodeMetastasisofRadioiodine-RefractoryThyroidCarcinomaLULu,JIANGZewen,ZHAOShousong,MOUXingyu,FUWei(DepartmentofNuclearMedicine,AffiliatedHospitalofGuilinMedicalUniversity,Guilin541001,China)Abstract:Thevastmajorityofpatientswithdifferentiatedthyroidcarcinomacanachieveagoodprognosisaftersurgery,radioiodinetherapy,andstimulatinghormonesuppressiontherapy.However,therearestillcertainamountoflocalordistantmetastasiscases,andthemostcommoniscervicallymphnodemetastasis.Somecervicallymphnodemetastaseslosetheabilitytoconcentrateradioiodineattheearlystageorduringradioiodinetherapy,anddevelopradioiodine-refractoryDTC(RAIR-DTC).RAIR-DTCcanseriouslyaffectpatients’prognosisandsurvivalrateandappeartobeabarrierofclinicaldiagnosisandtreatment.Inthispaper,therecentadvancesinthediagnosisandlocaltreatmentofcervicallymphnodemetastasisofRAIR-DTCaresummarized.Keywords:Thyroidcancer;Cervicallymphnodesmetastasis;Refractory;Localtreatment甲状腺癌(thyroidcarcinoma,TC)是最常见的内分泌恶性肿瘤之一,发病率持续上升,1990年我国TC的新发病例数为10030例,2019年为39080例,2039年预计为47820例[1]。甲状腺乳头状癌(papillarythyroidcarcinoma,PTC)、甲状腺滤泡细胞癌(follicularthyroidcarc...
