TGF-βattenuatestumourresponsetoPD-L1blockadebycontributingtoexclusionofTcellsSanjeevMariathasan1,*,^,ShannonJ.Turley1,*,^,DorotheeNickles1,*,AlessandraCastiglioni1,KobeYuen1,YuleiWang1,EdwardE.KadelIII1,HartmutKoeppen1,JillianL.Astarita1,RafaelCubas1,SuchitJhunjhunwala1,RomainBanchereau1,YagaiYang1,YinghuiGuan1,CecileChalouni1,JamesZiai1,YasinŞenbabaoğlu1,StephenSantoro1,DanielSheinson1,JeffreyHung1,JenniferM.Giltnane1,AndrewK.Pierce1,KathrynMesh1,SteveLianoglou1,JohannesRiegler1,RichardA.D.Carano1,PontusEriksson2,MattiasHoglund2,LoanSomarriba3,DanielL.Halligan3,MichielvanderHeijden4,YohannLoriot5,JonathanE.Rosenberg6,LawrenceFong7,IraMellman1,DanielS.Chen1,MarjorieGreen1,ChristinaDerleth1,GreggD.Fine1,PritiS.Hegde1,RichardBourgon1,^,andThomasPowles81Genentech,SouthSanFrancisco,California94080,USA2DivisionofOncologyandPathology,DepartmentofClinicalSciencesLund,LundUniversity,Lund,Skåne,SE-22381,Sweden3FiosGenomics,Edinburgh,ScotlandEH164UX,UK4NetherlandsCancerInstitute,1066CXAmsterdam,TheNetherlands5DepartmentofCancerMedicine,InstitutGustaveRoussy,UniversityofParisSud,94800Villejuif,France6GenitourinaryOncologyService,DepartmentofMedicine,MemorialSloanKetteringCancerCenter,NewYork,NewYork10065,USA7UniversityofCaliforniaSanFrancisco,HelenDillerFamilyComprehensiveCancerCenter,SanFrancisco,California94158,USA8BartsExperimentalCancerMedicineCentre,BartsCancerInstitute,QueenMaryUniversityofLondon,LondonEC1M6BQ,UKAbstractUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#terms^Co-correspondingauthors:SanjeevMariathasan,mariathasan.sanjeev@gene.com;ShannonTurley,turley.shannon@gene.com;RichardBourgon,bourgon.richard@gene.com.*Theseauthorscontributedequallytothiswork.AuthorcontributionsSM,SJT,DN,JR,LF,IM,DSC,MG,CD,GDF,PSH,RB,TPcontributedtotheoverallstudydesign.SM,SJT,DN,YW,EEK,KY,YG,YS,SL,PE,MH,LS,DLH,PSH,RBpe...
