mTORAktGSKp27PKCPLCSrcc-CblDokGAB2SHP-2CrkARF6PaxillinCalcineurinMIG6YesSykMuc1Caveolinβ-CatSpryJakE-cadherinFAKp130CasVav1Nck1PAK1MEKK1JNKRac1c-AblCalmodulinCaMKGRB2SOSRafMEKMEK2/3MEK5ERK5MAPKp70S6KStatMEF2MEF2FoxO1BadPSD95GEP100TSAdTAB2RasCREBElkStatShcGRB2TNS3TNS4PI3KEGFR/ErbB1EGFR/ErbB1HER2/ErbB2EGFR/ErbB1HER3/ErbB3HER2/ErbB2HER4/ErbB4HER2/ErbB2HER4/ErbB4EGFR/ErbB-1StatEGFR/ErbB-1E2FJunFosHER2/ErbB2CXCR4WT1Gab1XIAPCaspasecdc42ShcBDP1Memocdc2PLNADNA-PKHER4/ErbB4γ-SecTACEHER2/ICDStatHER4ICDN-CoRHER4ICDImportinβ1Nup358MDM2p53ProteinSynthesisCellSurvivalCellCycleCellAdhesionEGFEGFβCEL.NRG1NRG2NRG3NRG4NRG4HB-EGFTGF-αEPGAREGCytoskeletalRegulationCellMotilityTumorInvasionIncreaseCellMotilityInvasionMetastasisProliferationApoptosisSurvivalCellProliferation,Inflammation,GenomeInstability,TumorProgressionCellGrowth/Differentiation,CellShape,ChemotaxisGrowthDifferentiationCellularProliferation,DNARepairCellMigrationNucleusCytoplasmErbB/HERSignalingwww.cellsignal.com©2004–2010CellSignalingTechnology,Inc.ErbB/HERSignalingNetwork•createdOctober2004•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
