Suv39H1MycBMI1Myccdc25AMycp27Kip1p21Cip1p53MycSmad3Fox01/3Smad4ATM/ATRp15INK4Bp16INK4Ap18INK4CGSK-3βCyclinDCDK4/6CDK2Chk1/2AktCyclinERbRbAblE2FE2Fp19INK4DDP-1DP-1SCFSCFFoxO1HDACDNADamageTGF-βReplicativeSenescenceUltraVioletStressResponseGrowthFactorWithdrawalGrowthFactorReceptorActivationUbiquitinationReplicativeSenescenceUbiquitinationUbiquitinationE2F/DPTargetGenes:CyclinE/A,E2F-1/2/3,cdc2,c-Myc,p107,RanGAP,TK,DHFR,PCNA,H2A,etc.ONOFFG1-PHASERS-PHASEDifferentiationDBEBimFasLTRAILApoptosisHormonesCellCycleControl:G1/SCheckpointwww.cellsignal.com©2002–2010CellSignalingTechnology,Inc.CellCycleControl:G1/SCheckpoint•createdNovember2002•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
