胰岛素样生长因子在肥胖发生发展中的作用*丁凤1,张炜真2,尹悦3,△(1北京大学第三医院;2北京大学基础医学院生理与病理生理学系;3北京大学基础医学院药理学系,北京100191)摘要近年来,肥胖的发病率逐年上升,给人类健康和社会经济带来严重负担。胰岛素样生长因子(insulin-likegrowthfactor)是一种化学结构上与胰岛素高度同源的多肽物质,参与机体多种物质的代谢,与肥胖的发生发展密切相关。本文将概述胰岛素样生长因子轴的组成,重点综述胰岛素样生长因子在肥胖发生发展中的作用及其相关机制,为肥胖的防治提供新的思路和策略。关键词胰岛素样生长因子;IGF-1;IGF-2;肥胖中图分类号R335TheRoleofInsulin-LikeGrowthFactorintheDevelopmentofObesity*DINGFeng1,ZHANGWei-Zhen2,YINYue3,△(1TheThirdHospitalofPekingUniversity;2DepartmentofPhysiolo-gyandPathophysiology,SchoolofBasicMedicalSciences,HealthScienceCenter,PekingU-niversity;3DepartmentofPharmacology,SchoolofBasicMedicalSciences,PekingUniversi-ty,Beijing100191,China)AbstractInrecentyears,theincidenceofobesityhasbeenincreasing,bringingaseriousburdentohumanhealthandthesocialeconomy.Insulin-likegrowthfactor(IGF)isapolypeptidehighlyhomologouswithinsulininstructure,whichparticipatesinthemetabolismofvarioussubstancesinthebodyandiscloselyrelatedtotheoccurrenceanddevelopmentofobesity.Thisarticleout-linesthecompositionoftheIGFaxisandfocusesontheroleofIGFinthedevelopmentofobesityaswellastheunderlyingmechanisms,aimingtoprovidenewideasandstrategiesforthepreven-tionandtreatmentofobesity.Keywordsinsulin-likegrowthfactor;IGF-1;IGF-2;obesity引用格式:丁凤,张炜真,尹悦.胰岛素样生长因子在肥胖发生发展中的作用.生理科学进展,2023,54(4)︰297~303DINGFeng,ZHANGWei-Zhen,YINYue.TheRoleofInsulin-LikeGrowthFactorintheDevelopmentofObesity.ProgressinPhysiologicalSciences,2023,54(4)︰297~303.DOI:10.20059/j.cnki.pps.2023.02.1119肥胖是一种代谢综合征,源于机体脂肪蓄积而引起的体内能量代谢失衡[1],脂肪细胞数量增加和体积增大是肥胖患者的主要病理学改变[2]。随着体质量增加,多种炎症因子的含量也同时增加,因此目前的一些观点认为肥胖也是一种慢性炎症状态[3]。肥胖的发病率逐年上升,在过去50年中,全球肥胖的流行率增加了两倍,目前...
